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br Material and methods br Acknowledgement We thank Jane Hag
2018-11-08
Material and methods Acknowledgement We thank Jane Hagelskjær Knudsen, Christian Knudsen, and Bettina Hansen for excellent technical assistance. This project was supported by Aarhus University and partially by the Lundbeck Foundation (R151-2013-14439) and Danish Council for Independent Researc
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br Introduction Mammary gland development is controlled by
2018-11-08
Introduction Mammary gland development is controlled by the endocrine system, in particular by the ovarian steroid hormones, estrogen and progesterone, and by the pituitary hormones, growth hormone (GH) and prolactin. Studies in animal models showed that GH deficiency impairs mammary gland develo
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Effective differentiation of hPSCs into DE is
2018-11-08
Effective differentiation of hPSCs into DE is coupled with the suppression of E-CADHERIN/CDH1 and pluripotency. Whereas BMP signaling has been reported to suppress E-CADHERIN/CDH1 and pluripotency (Teo et al., 2011, 2012), we observed that WNT3A is not as effective as GSK-3 inhibitors in suppressing
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In summary this study revealed the unexpected
2018-11-08
In summary, this study revealed the unexpected capacity of Sox2 for converting reactive glial cells into induced DCX+ neurons in the injured cerebral cortex. Our work highlights the potential of NG2 glia as cellular candidates for de novo generation of new neurons in the cerebral cortex, a NCT-501 m
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Complementary approaches to visualizing the CSCs have taken
2018-11-08
Complementary approaches to visualizing the CSCs have taken advantage of different biological properties of the tumor hierarchy, such as low expression of 26S proteasome activity in CSCs (Vlashi et al., 2009) or high expression of LET7C in differentiated aldehyde dehydrogenase inhibitor (Ibarra et a
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CXCR is a widely expressed chemokine
2018-11-08
CXCR4 is a widely expressed chemokine receptor that is essential for development, hematopoiesis, organogenesis, and vascularization (Busillo and Benovic, 2007). The CXCR4/SDF-1 axis is important in cardiac development as evidenced by the observed cardiac phenotype in knockout transgenic strains (Nag
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Importantly STS and STS have been shown
2018-11-08
Importantly, STS1 and STS2 have been shown to have overlapping functions (Carpino et al., 2002; Carpino et al., 2004). However, although expansion of LSK, increased serial colony growth, and hyperphosphorylation of FLT3 were largely attributable to the loss of STS1, further loss of STS2 strengthened
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br Introduction In mammals cells from the blastocyst stage c
2018-11-08
Introduction In mammals, cells from the neuroscience peptides stage can be used to form embryonic stem (ES) cell lines that can self-renew in culture while maintaining the ability to differentiate into cells of the three germ layers (Reubinoff et al., 2000). Directed in vitro differentiation pro
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Current gene editing techniques generate heterogeneous human
2018-11-08
Current gene-editing techniques generate heterogeneous human cell populations that require significant subsequent characterization. It is crucial to analyze the genome of the edited jnk pathway by sequencing before continuing with other studies, and several protocols require destruction of mutant c
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br Results br Discussion Yamanaka
2018-11-08
Results Discussion Yamanaka factors induce somatic cell reprogramming to iPSCs by promoting spatiotemporal expression of PSC-specific and metabolic genes. However, only a small fraction of these Panobinostat complete full reprogramming, leaving most cells at an intermediate stage (Chan et al.
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To determine tissue specificity in
2018-11-07
To determine tissue specificity in CESC differentiation, we performed chondrogenic and osteogenic induction under normoxia and hypoxia, respectively. Our study revealed tissue specificity indicating that hypoxia promoted chondrogenesis but inhibited osteogenesis in CESCs. This tissue specificity of
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br Data and methods br Results Overweight
2018-11-07
Data and methods Results Overweight was more common among males than among females (Table 1). The mean number of respondents per municipality was lower among the overweight compared with non-overweight; however, no difference was found by age. In both females and males, the overweight prevalen
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Capillary electrophoresis coupled to mass spectrometry CE MS
2018-11-07
Capillary electrophoresis coupled to mass spectrometry (CE–MS) is a sensitive proteomic analytical technique that is robust with high reproducibility of results in an acceptable time frame [11]. In CE–MS, capillary zone electrophoresis is interfaced with high resolution mass spectrometry; electropho
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Pre mbulo br L mites
2018-11-07
Preámbulo Límites y cambios paradigmáticos Conclusiones Como se ha examinado, las ideas que orientaron el desarrollo institucional y político de gran parte de los países han visto empequeñecer su antigua eficacia socio-política o generado dilemas imprevistos donde destaca el de la igualdad (D
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br Discussion Standardized case ascertainment based on pre
2018-11-07
Discussion Standardized case ascertainment based on pre-defined case definitions has been shown to be reproducible and consistent (Rath et al., 2010; Muehlhans et al., 2012). The retrospective classification of clinical cases however, is often challenged by missing data in medical records, thus
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