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Introduction By catalyzing post translational acetylation of
2019-06-10
Introduction By catalyzing post-translational acetylation of lysine residues, the histone acetyl transferases (HAT) CREBBP and EP300 moderate the activities of both histone and non-histone proteins. This regulates vital cellular processes such as cell cycling and apoptosis by modulating chromatin s
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NCT-501 br Environmental pollution is a global problem and t
2019-06-10
Environmental pollution is a global problem and the subject of increasing worldwide public health concern. In particular, air pollution is regarded as the largest single environmental risk to health. More than 80% of people living in urban areas that monitor air pollution are exposed to air qualit
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In the wake of these commitments comes
2019-06-10
In the wake of these commitments comes a reminder of the enormity of the task at hand. In , Alexandre Delamou and colleagues present data on the lasting effect of the Ebola virus disease epidemic on maternal and child health-care services in the rural Forest region of Guinea—the location of approxim
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Several true lumen re entry
2019-06-10
Several true lumen re-entry devices have been introduced into the market, including the Outback catheter, allowing fluoroscopically controlled true arterial lumen re-entry after subintimal guidewire passage. A recent retrospective review reported a successful re-entry rate of 91% in 11 patients with
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hiv protease inhibitors Recently denosumab demonstrated a si
2019-06-10
Recently, denosumab demonstrated a significant delay in the onset of detectable bone lesions in men with castration resistant prostate cancer compared to placebo . This could indicate some kind of efficacy of the compound as anticancer agent and consequently an indirect confirmation of the role of R
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br Specific concerns of each VT substrate
2019-06-06
Specific concerns of each VT substrate Complications Potential complications associated with epicardial catheter ablation of VTs are very rare and the procedures are generally safe [4–6,11,13–16,17,25,33–35]. However, transthoracic epicardial access and ablation could result in uncommon compli
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caspofungin Stigma and discrimination experienced by sex
2019-06-06
Stigma and discrimination experienced by sex workers, injection drug users, and men who have sex with men is tough to tackle. Responses need to be tailored to very different circumstances and require interventions on several levels: policy, societal, health system, and individual. There is no magic
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br Discussion A familial platelet disorder with
2019-06-06
Discussion A familial platelet disorder with a propensity to myeloid malignancy (FPD/MM) was first reported in 1978 and since then approximately 30 pedigrees with RUNX1 germline mutations have been reported in the literature [9,11]. The RUNX1 gene is composed of 10 exons (1–6, 7A, 7B, 7C and 8).
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First progress towards the targets should
2019-06-06
First, progress towards the 2020 targets should be measured through collation, presentation, and analysis of standardised core metrics that track country progress. Elimination and control targets in the WHO Roadmap could serve as initial standardised metrics. Efforts are being made to measure the pr
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Catheter ablation of a concealed right anteroseptal
2019-06-06
Catheter ablation of a concealed right anteroseptal AV bypass tract was successfully performed in our patient. Catheter ablation of the anteroseptal accessory pathway did not affect normal AV conduction. The effective refractory period of the fast AV node was 380ms at a pacing order olopatadine hcl
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Cisplatin based chemotherapy is commonly used in adjuvant CC
2019-06-06
Cisplatin-based chemotherapy is commonly used in adjuvant CCRT, but data on carboplatin-based chemotherapy with radiotherapy is lacking. Khoury et al reported that patients treated with carboplatin-based chemoradiotherapy show worse outcomes. However, the impact on patient comorbidities was not repo
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br Patients and methods br Results br Discussion In the
2019-06-06
Patients and methods Results Discussion In the ZOTECT study, ZOL therapy was associated with significantly decreased P1NP and CTX levels within 1 month of initiating treatment (PH 89 with data from a small trial in patients with newly diagnosed bone metastases from PC, BC, or lung cancer (
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br Discussion br Conflict of interest br Introduction Device
2019-06-06
Discussion Conflict of interest Introduction Device implantations may be challenging in patients with venous abnormalities. The most common congenital variation, frequently associated with other congenital abnormalities, is a persistent left superior vena cava (PLSVC), and successful atrial
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Modelling studies have estimated that the implementation of
2019-06-06
Modelling studies have estimated that the implementation of Xpert MTB/RIF, either in addition to or as a replacement to smear microscopy, will be cost-effective for the diagnosis of tuberculosis and mutidrug-resistant (MDR) tuberculosis in countries with a high burden. The incremental cost of each d
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Desde mediados de la d cada de
2019-06-06
Desde mediados de la década de los sesenta, la embajada argentina pedía informes sobre las actividades políticas en general y sobre las consideradas subversivas en Guatemala. A juicio de la embajada, en 1978 no se podía analizar la “ola de violencia” en Guatemala sin incluirla en el contexto de lo q
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