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Finally the identification of predictive biomarkers of respo
2019-08-27
Finally, the identification of predictive biomarkers of response will also allow the more recently discovered CDK inhibitors to be explored in particular genetically-defined contexts, for example by building on recent observations that KRAS mutant tumors are highly sensitive to CDK1 inhibition, and
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br Dienogest DNG Dienogest is a nortestosterone derivative
2019-08-27
Dienogest (DNG) Dienogest is a 19-nortestosterone derivative with two special structural changes [Fig. 1a]: [a] At the cabon-17 position there is a cyanomethyl group instead of an ethinyl group; [b] A double bond is present between carbons 9 and 10. DNG is the only progestogen that combines prope
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We then analyzed Ki proliferation
2019-08-27
We then analyzed Ki-67 proliferation index as a categorical variable by using 15%, essentially the median Ki-67 value in the entire study group (see above), to delineate low and high proliferation subgroups. By Fisher\'s exact test, both the type 1 versus non-type 1 EWS-FLI1 comparison (P = 0.047; T
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In order to evaluate the
2019-08-27
In order to evaluate the in vivo pharmacology associated with EP receptor antagonism, we wished to discover antagonists presenting a higher degree of selectivity over the other prostanoid receptors. We also wanted to increase the brain–blood ratio since it is probable that centrally mediated EP agon
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In another study Nutlin a mediated
2019-08-27
In another study, Nutlin-3a-mediated p53 activation induced strong negative impact on NF-κB signaling in LPS-stimulated neutrophils and macrophages [34]. Nutlin-3a limited cellular immune response to LPS, partly by attenuating DNA binding activity of NF-κB and impairing transcription of its target c
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br Results br Discussion Taking advantage of the
2019-08-27
Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate Z-Ligustilide pathway that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 in
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br Epac in cardiovascular pathophysiology Epac orchestrates
2019-08-26
Epac in cardiovascular pathophysiology Epac orchestrates signaling actors that regulate fundamental cellular functions and general biological effects. However, some important gaps still remain in the knowledge of the physiopathological role of Epac in the heart. So far, Epac has been implicated i
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Herbal products may alter the metabolism of
2019-08-26
Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 A 77-01 (CYP). These can bring about an alteration of the pharmacokinetics and pharmacological activi
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A number of factors have been shown to remove blocking
2019-08-26
A number of factors have been shown to remove blocking end groups in order to make the termini of DSBs ligatable. A common non-ligatable end is one that contains either a 3′ phosphate or 5′ hydroxyl. The polynucleotide kinase/phosphatase (PNKP) is the NHEJ processing enzyme responsible for removing
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XL-888 Interest in DGKs increased as it became clear that
2019-08-26
Interest in DGKs increased as it became clear that not only are they important for lipid homeostasis, they serve to modulate the relative levels of diacylglycerol (DAG) and phosphatidic XL-888 (PtdOH) that play critical roles in a variety of signaling pathways (Eichmann and Lass, 2015; Liu et al.,
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To compare glucose metabolism via oxidative phosphorylation
2019-08-26
To compare glucose metabolism via oxidative phosphorylation to that via glycolysis, a bioenergetics plot was constructed (Fig. 3A). In most cells, a decrease in one bioenergetics pathway is compensated by an increase in the other. However, following NAT1 deletion, there was a decrease in both oxidat
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Furthermore we explored the effect of PKC on SIRT phosphoryl
2019-08-26
Furthermore, we explored the effect of PKCζ on SIRT6 phosphorylation. Accumulating data showed that aPKC isoforms are involved in regulating lipid metabolism [41], [42], [43], [44], [45], [46], [47]. The aPKC activity was reported to play a dominant role in normal insulin signaling by activating PI3
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In previous works Wang et al the PR CPA EoS
2019-08-26
In previous works (Wang et al. [4,5]), the PR-CPA EoS has been applied to describe the solubilities of hydrocarbons (including methane, ethane, propane, n-butane, n-pentane, n-hexane, benzene, toluene, and ethyl-benzene) and mercaptans (including methyl mercaptan and ethyl mercaptan) in aqueous MDEA
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The main variable of the study was whether
2019-08-26
The main variable of the study was whether there was an association between the COMT Val158Met polymorphism and motor behavior. Additionally, it was investigated whether the effects of the COMT genotypes on the role played by tonic/phasic DA are associated with the stability/flexibility nature of th
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Noteworthy the transient downregulation of the
2019-08-26
Noteworthy, the transient downregulation of the regulatory CK2β subunit reduces HSP27 expression in all the three different human cell lines (Fig. 2b). Similarly, the downregulation of one of the two catalytic subunits, CK2α or CK2α′, is sufficient to affect HSP27 expression without affecting other
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