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Water inorganic salts sugars lipids nucleic acids and protei
2019-09-23
Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and
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hydrochloride In conclusion BmSpry was targeted by three vir
2019-09-23
In conclusion, BmSpry was targeted by three viruses to regulate the ERK pathway and thus ensure viral reproduction in the silkworm. This is the first report regarding a general mechanism of host regulation by multiple silkworm viruses, and this can pave the way for future virus control in other inse
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br Introduction Hydrogen sulfide H S and nitric oxide NO
2019-09-23
Introduction Hydrogen sulfide (H2S) and nitric oxide (NO) are important gasotransmitters in the cardiovascular system and instrumental to the fine control of vascular tone [1] and cellular function [2]. NO is synthesized from l-arginine by calmodulin-dependent endothelial nitric oxide synthase (e
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br Transparency document br Introduction Cigarette smoke
2019-09-23
Transparency document Introduction Cigarette smoke is modifiable factors to alter the neurovascular functions. Now a day, cigarette smoking in public place is offense due to toxic exposure cause the neurological and respiratory system damage to non-smoker population [1]. A literature survey ex
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br Conclusion br Introduction br
2019-09-23
Conclusion Introduction CRL4 E3 ligases in tumorigenesis Small molecule-based PROTACs PROTAC: Major biological impacts Acknowledgements The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank th
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AM095 The yeast Rad p radiation sensitive also called Ubc E
2019-09-23
The yeast Rad6p (radiation sensitive 6, also called Ubc2) E2 ubiquitin-conjugating enzyme is a member of the highly conserved UBC proteins in eukaryotes (Xu et al., 2009). Rad6p is involved in several cellular processes, including DNA repair, transcriptional activation and silencing, histone ubiquit
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DNA bound Ku proteins recruit DNA PKcs
2019-09-23
DNA-bound Ku proteins recruit DNA-PKcs; and thereby translocate into the duplex by one helical turn, leaving DNA-PKcs near the DNA terminus to assist in tethering the broken ends together [25]. In addition to keeping the DSBs in close proximity, DNA-PKcs may prevent exonucleolytic degradation of the
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In conclusion adipose PGD suppressed the lipolysis by decrea
2019-09-23
In conclusion, adipose PGD2 suppressed the lipolysis by decreasing the intracellular cAMP level through DP2R. Therefore, PGD2 enhanced adipocyte differentiation (lipid accumulation) through both repression of the lipolysis via DP2R and activation of the lipogenesis via PPARγ. Thus, L-PGDS and DP2R a
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This review focuses on the atomic
2019-09-23
This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t
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kinesin spindle protein br Experimental section br Results b
2019-09-23
Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised kinesin spindle protein did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in
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Our module is designed to allow
2019-09-23
Our module is designed to allow in-process measurement of [C]-tracer molar activity (MA, GBq/μmol at EOB) using a Neuregulin/Heregulin-1β (NRG-1β/HRG-1β), human recombinant protein kinase detector with a UV detector at the outlet of the HPLC-portion of the system. In the HPLC chromatogram, peak anal
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br Conflict of interest statement br Acknowledgements br
2019-09-23
Conflict of interest statement Acknowledgements Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people. Although during the last century their lifespans increased, the so-called “old-age diseases” became more and mo
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The upregulation of PTGS and PTGS in late gestation
2019-09-23
The upregulation of PTGS1 and PTGS2 in late gestation in mares could be linked to the high levels of estrogens produced by the fetoplacental unit. Estrogens are thought to be effective stimulators of prostaglandin production by potentially up regulating PTGS2 expression. Although a recent publicatio
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Here we report that ILC s
2019-09-23
Here, we report that ILC3s sensed oxysterols through GPR183, which was highly expressed by LTi-like ILC3s. 7α,25-OHC-synthesizing enzymes were produced by fibroblastic stromal IWR-1-endo found in intestinal lymphoid structures, and the GPR183 ligand 7α,25-OHC acted as a chemoattractant for ILC3s. G
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In this study we observed alterations in mRNA levels
2019-09-21
In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased CPI-455 when the sensitization condition was established. Similarly, CRF2 receptor increase
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