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DNA methylation is a relatively
2019-10-10
DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla
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Khan et al studied the effects
2019-10-10
Khan et al. studied the effects of two structurally divergent coumarins viz calipteryxin 3 and (3′S,4′S)-3′,4′-disenecioyloxy-3′,4′-dihydroseselin 4 from Seseli recinosum, in lipopolysaccharide (LPS)-stimulated murine macrophages. The study revealed that calipteryxin and (3′S,4′S)-3′,4′-disenecioylo
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Soon after the discovery of ET and
2019-10-10
Soon after the discovery of ET1 and the cloning of its ETA and ETB receptors, low-molecular-weight compounds were identified that can prevent the binding and effects of radioactively labeled ET1 3, 5, 6, 8. Initially, these ERAs resulted from screening efforts (e.g. BQ123 39, 49 and bosentan [50]).
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Several studies have already shown
2019-10-10
Several studies have already shown that mPR activation can significantly reduce intracellular cAMP levels in different kind of cells, such as GT1-7 neuronal cells [32], MDA-MB-468 breast cancer cells [55] and primary vascular endothelial cells [56]. The experiments performed with PTXa and 8-Br-cAMP
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Our results are the first
2019-10-10
Our results are the first to demonstrate that ERRγ acts as a catabolic regulator of cartilage degeneration and OA pathogenesis, and collectively support the idea that ERRγ could be a therapeutic target for OA Introduction DNA cytosine-5-methyltransferases (Dnmts) catalyze the methyl transfer fr
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br Introduction Rhabdomyosarcoma RMS is a
2019-10-10
Introduction Rhabdomyosarcoma (RMS) is a myogenic tumor that accounts for approximately 50% of all pediatric soft tissue sarcomas. Diagnostic criteria for RMS S/GSK1349572 on the validation of proteins of the skeletal muscle lineage, such as Desmin, MyoD or Myogenin [1]. RMS cells are persistent
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br Results br Discussion C is related to another
2019-10-09
Results Discussion C4 is related to another VACV protein, C16, and the C-terminal domain of C16 also inhibits DNA-PK-mediated DNA sensing via the same mechanism and to a similar level as C4. Moreover, mutagenesis of C16 at the CYC residues equivalent to those in C4 abrogated the C16-Ku interac
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Sterol regulatory element binding proteins SREBPs regulate t
2019-10-09
Sterol regulatory element binding proteins (SREBPs) regulate transcription of genes involved in fatty hesperetin synthesis [38] (fatty acid synthase, and acetyl-CoA carboxylase) as well as triglyceride synthesis [39]. SREBP-1 protein levels are reduced in 3T3-F442A adipocytes [40] and increased in
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Notochord is a transient structure differentiating at early
2019-10-09
Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated Fluticasone propionate surrounded by a unique ECM structure improperly called notochordal BM. As in chicken
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The development and activation of T cells play an
2019-10-09
The development and activation of T Rufinamide pathway play an important role in the progression of atherosclerosis. As for activation and differentiation of T cells, TCR signalling pathway is pivotal. ZAP70 plays a crucial role in formulation of TCR–microclusters, initiation of TCR signalling pathw
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br Enzyme activations Activated proteinases can unleash a de
2019-10-09
Enzyme activations Activated proteinases can unleash a deluge of tissue damage (Zucker et al., 2009). Once activated, the essential enzymes such as serine proteases and cysteine proteases cannot discriminate between self and non-self, burning away self-tissues (Chien et al., 2009, Laskar et al.,
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Results of the present study demonstrate
2019-10-09
Results of the present study demonstrate that 25-OHC treatment of THP-1 monocytes induced vimentin intermediate filament reorganization to more cortical structures and a polarized phenotype (Fig. 5). Vimentin is the major intermediate filament protein present in leukocytes and plays an important rol
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br Conclusion In conclusion DNA methylation is
2019-10-09
Conclusion In conclusion, DNA methylation is a major epigenetic mark, which regulates temporal and spatial expression of the testicular genes required for normal spermatogenesis process. There are two types of methylation, maintenance and de novo methylation, which are catalysed by DNMT1, DNMT3A
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66 4 mass Some mechanistic experiments performed in the earl
2019-10-09
Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects 66 4 mass from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This evidence
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Tropical theileriosis is caused by the apicomplexan
2019-10-08
Tropical theileriosis is caused by the apicomplexan parasite Theileria annulata which is transmitted by a tick vector from the genus Hyalomma in cattle (Echebli et al., 2014, Li et al., 2014). Theileria parasites invade the leukocytes by sporozoites secreted from the vector, schizonts mature into me
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