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POE specialises Rogers definition of engineering to
2020-08-11
POE specialises Rogers\' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that QS 11 meets a real-world need N to the satisfaction of a group of stakeho
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Another interesting study was that
2020-08-11
Another interesting study was that by Kotyuk et al. (2015), who investigated the association between COMT rs4680 and personality in elderly people. The authors analysed the association between COMT rs4680 and NEO-FFI. The GG idasanutlin correlated with lower mean Neuroticism score and higher Agreea
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Assessment of DNA damage by comet assay and
2020-08-11
Assessment of DNA damage by comet assay and ChEs activity has been widely used as a biomarker of genotoxicity and exposure to pesticide respectively, to measure the risk related to pesticides in the exposed population [15]. Very few studies have explored the association between DNA damage and worker
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Of all the residues of plants
2020-08-11
Of all the residues of plants, the ash obtained from the incineration of RH has highest amount of silica content [7]. The rice crop normally ingest orthosilicic ag1478 mg in large quantity from ground water and this acid is further polymerized in the husk, ultimately contribute to amorphous silica [
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To develop antagonists selective for the mouse EP receptor w
2020-08-11
To develop antagonists selective for the mouse EP1 receptor, we started with compound (), synthesized as previously described (). Diethyl dipicolinic Sirolimus () was reduced with NaBH to . Parikh–Doering oxidation of with sulfur trioxide–pyridine complex and DMSO produced the unstable aldehyde . 4-
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The aim of the following work was to untap the
2020-08-11
The aim of the following work was to untap the potential of DIS as a low-cost substrate for fungal production of lignocellulolytic enzymes via SSF. Fungal strains with the ability to transform the unpretreated DIS to a mixture of industrially relevant lignocellulases were identified. Furthermore, th
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Examination of Wnt signaling via for example
2020-08-10
Examination of Wnt signaling via, for example, complexes of frizzled (Fz) and lipoprotein-receptor-related protein (LRP) receptors has been hindered by difficulties in producing Wnt ligands due to their inherent hydrophobicity [20]. This bottleneck was recently bypassed by constructing highly solubl
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Soluble receptors have been shown to be important and
2020-08-10
Soluble receptors have been shown to be important and common regulators of many cytokines within the immune system, including IL-1, IL-6, IFNγ, TNF-α, GM-CSF, G-CSF and others (Fernandez-Botran, 1991, Heaney, Golde, 1998). We previously described a novel soluble receptor, sCSF-1R, that to date has o
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br Materials and methods br
2020-08-10
Materials and methods Results Discussion Chicken thrombocyte stimulation with LPS leads to a number of inflammatory responses through TLR4-linked pathways (Scott and Owens, 2008). In mammals, LPS binds to LPS-binding protein (LBP) in the blood serum and this complex is subsequently recogniz
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The expression profiles of NCK and ABI genes after
2020-08-10
The expression profiles of NCK and ABI genes after ESC bacterial infection were determined. As shown in Fig. 1a, NCK1, ABI2a and ABI2b were significantly induced after ESC infection. While, ABI3a was significantly downregulated. Intestine was confirmed as a site of E. ictaluri entry by bacteriologic
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WEHI-539 We then analyzed Ki proliferation
2020-08-10
We then analyzed Ki-67 proliferation index as a categorical variable by using 15%, essentially the median Ki-67 value in the entire study group (see above), to delineate low and high proliferation subgroups. By Fisher\'s exact test, both the type 1 versus non-type 1 EWS-FLI1 comparison (P = 0.047; T
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We obtained two bands in RT PCR
2020-08-10
We obtained two bands in RT-PCR for detection of SERPIN1-FOSB fusion when Taq DNA polymerase was used (Fig. 3A). Genuine RT-PCR product of SERPIN1-FOSB fusion was proved to be the shorter one (733 Ellipticine synthesis pairs) by sequencing, and the longer band (863 base pairs) was shown to be deriv
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br Conflicts of interest br Author contributions br Acknowle
2020-08-10
Conflicts of interest Author contributions Acknowledgements This work was supported by the University of Brescia (ex 60%) and Siderurgica Leonessa research funds to AF. RR was supported by Associazione Italiana per la Ricerca sul Cancro - AIRC (MFAG 18459 grant). We are grateful to Umberto
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Because of the lack of sequence
2020-08-10
Because of the lack of sequence, current knowledge on the cellular regulation of CoA-IT is scarce. However, recent work has suggested an interesting new role for CoA-IT in regulating the extent of the AA mobilization response in primed macrophages. Bacterial lipopolysaccharide (LPS) is a poor trigge
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br Clinical potential of ET
2020-08-10
Clinical potential of ET receptor biased ligands Is there a clinical need for ET receptor biased ligands? Evidence is strongest from research in epithelial ovarian cancer demonstrating that ET-1 stimulated ETA-mediated β-arrestin signalling leads to activation of the oncogenic mediator NF-κB [21]
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