• The contribution of local ETA and ETB

  2020-12-12

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor ON123300 in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies have

• Immunomodulation effects of certain oxysterols were previous

  2020-12-12

  

  Immunomodulation effects of certain oxysterols were previously shown to depend on activation of oxysterol-binding liver X receptors (LXRs). Recent work from our labs as well as from others has shown additional receptors linking oxysterols and immunity. For example, we found that 7α,25-dihydroxychole

• Why are Tfh cell dynamics so fundamentally different in

  2020-12-12

  

  Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC kanamycin synthesis must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest

• The DNA damage response DDR is

  2020-12-12

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as SJ 172550 regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been recogn

• br Introduction A variety of means including

  2020-12-12

  

  Introduction A variety of means, including UV irradiation, dNTP depletion, and oncogene activation at precancerous lesions, induce replication stress, which causes replication errors if left undealt with (Hills and Diffley, 2014, Zeman and Cimprich, 2014). Eukaryotic cells have developed the DNA

• br DAG kinase activity is confined to specific cell compartm

  2020-12-12

  

  DAG kinase activity is confined to specific cell compartments A number of reports demonstrating agonist-dependent translocation of DGKs to distinct membrane compartments suggest that DGK activity is restricted to localized DAG pools generated after activation of receptors. Perhaps the best eviden

• Behaviors were compared between saline

  2020-12-11

  

  Behaviors were compared between saline and amphetamine pre-treatment groups at 24h and 2 weeks following the last treatment, or between pre-treatment groups that received vehicle or ASV-30 infusions, using separate two-way ANOVAs. Significant effects were analyzed further using Student–Newman–Keuls

• The mechanisms in the central nervous system CNS controlling

  2020-12-11

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the alpha adrenergic receptors are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by

• To the best of our knowledge this study

  2020-12-11

  

  To the best of our knowledge, this study was the first to demonstrate in vitro and in vivo that the lipolytic effect of kinsenoside results from coordination between PKA and AMPK pathways. We validated the lipolytic effect of kinsenoside in vivo and the effect of PKA activation on the modulating AMP

• The interest for lanthanide and

  2020-12-11

  

  The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte

• br Acknowledgments This work was funded by the

  2020-12-11

  

  Acknowledgments This work was funded by the EU ERDF and the Spanish Ministry of Economy and Competitiveness (MINECO) under Project TIN2013-41576-R, and the Spanish Ministry of Education, Culture and Sport (MECD) under a FPU grant (AP2010-3259), and the Andalusian Regional Government (Spain) under

• IAA sensitive Cl channels were shown to mediate

  2020-12-11

  

  IAA-94-sensitive Cl channels were shown to mediate cardioprotection due to IPC (Diaz et al., 1999) and cyclosporine A (Diaz et al., 2013). CLIC-like channel activity was also observed in cardiac mitoplast (Misak et al., 2013) but the molecular identity of these intracellular Cl channels and their p

• br Estrogen receptors activate mGluR

  2020-12-11

  

  Estrogen receptors activate mGluR signaling pathways In order to distinguish the opposing effects of estradiol on CREB phosphorylation, we turned to a “bottom-up” approach, working backwards from CREB phosphorylation to pharmacologically isolate the two signaling pathways (Boulware et al., 2005).

• Since clinical studies mostly involved cases that used

  2020-12-11

  

  Since clinical studies mostly involved cases that used MPA, data from studies that examined other types of progestogens are very limited. While the WHI study examined the combination of conjugated equine estrogens plus MPA [1], the Million Women Study [2] that also demonstrated an increased risk of

• br Introduction Cell transplantation therapies using

  2020-12-11

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or NBI 27914 hydrochloride have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups

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