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Case report The patient was referred to the oral and
2020-12-14
Case report The patient was referred to the oral and maxillofacial department at the authors’ institution for further evaluation and treatment. The patient underwent tumor resection with left hemi-mandibulectomy with wide bony margins (Fig. 1A), and mandible reconstruction with fibula free flap and
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The following are the supplementary data related to this art
2020-12-14
The following are the supplementary data related to this article. Acknowledgments Introduction Cyclooxygenases metabolize arachidonic HPK 56 to five primary prostanoids, PGE2, PGF2, PGI2, TXA2 (TX), and PGD2. These lipid mediators interact with specific members of a family of distinct G-prot
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Although information regarding the influence of PGE on
2020-12-14
Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no
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Nitric oxide synthase NOS is a predominant enzyme
2020-12-14
Nitric oxide synthase (NOS) is a predominant enzyme of immune system, which elaborates nitric oxide (NO) from the amino CCT251545 arginine (Arg). NO mediates vasodilatation, blood pressure regulation, neurotransmission, host defense, and macrophage-mediated immunity, among an array of other functio
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The contribution of local ETA and ETB
2020-12-12
The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor ON123300 in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies have
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Immunomodulation effects of certain oxysterols were previous
2020-12-12
Immunomodulation effects of certain oxysterols were previously shown to depend on activation of oxysterol-binding liver X receptors (LXRs). Recent work from our labs as well as from others has shown additional receptors linking oxysterols and immunity. For example, we found that 7α,25-dihydroxychole
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Why are Tfh cell dynamics so fundamentally different in
2020-12-12
Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC kanamycin synthesis must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest
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The DNA damage response DDR is
2020-12-12
The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as SJ 172550 regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been recogn
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br Introduction A variety of means including
2020-12-12
Introduction A variety of means, including UV irradiation, dNTP depletion, and oncogene activation at precancerous lesions, induce replication stress, which causes replication errors if left undealt with (Hills and Diffley, 2014, Zeman and Cimprich, 2014). Eukaryotic cells have developed the DNA
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br DAG kinase activity is confined to specific cell compartm
2020-12-12
DAG kinase activity is confined to specific cell compartments A number of reports demonstrating agonist-dependent translocation of DGKs to distinct membrane compartments suggest that DGK activity is restricted to localized DAG pools generated after activation of receptors. Perhaps the best eviden
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Behaviors were compared between saline
2020-12-11
Behaviors were compared between saline and amphetamine pre-treatment groups at 24h and 2 weeks following the last treatment, or between pre-treatment groups that received vehicle or ASV-30 infusions, using separate two-way ANOVAs. Significant effects were analyzed further using Student–Newman–Keuls
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The mechanisms in the central nervous system CNS controlling
2020-12-11
The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the alpha adrenergic receptors are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by
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To the best of our knowledge this study
2020-12-11
To the best of our knowledge, this study was the first to demonstrate in vitro and in vivo that the lipolytic effect of kinsenoside results from coordination between PKA and AMPK pathways. We validated the lipolytic effect of kinsenoside in vivo and the effect of PKA activation on the modulating AMP
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The interest for lanthanide and
2020-12-11
The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte
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br Acknowledgments This work was funded by the
2020-12-11
Acknowledgments This work was funded by the EU ERDF and the Spanish Ministry of Economy and Competitiveness (MINECO) under Project TIN2013-41576-R, and the Spanish Ministry of Education, Culture and Sport (MECD) under a FPU grant (AP2010-3259), and the Andalusian Regional Government (Spain) under
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