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FPS-ZM1 Previously we reported that EL Kras mice fed diets r
2024-06-04
Previously, we reported that EL-Kras mice-fed diets rich in omega-6 FAs demonstrated increased pancreatic mast cell infiltration [16]. Significantly, increased infiltration of mast cells into the tumor microenvironment correlates with a poor prognosis [15]. Soucek et al.[25] demonstrated that mast c
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Introduction Cancer which is responsible
2024-06-04
Introduction Cancer, which is responsible for a million deaths each year, is universally feared, and approximately 50% of newly diagnosed cases can be cured [1]. The existing cancer treatments, including surgery, chemotherapy, radiotherapy or a combination of them, are quickly losing efficacy. The
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Autotaxin has been linked to chemoresistance through its
2024-06-04
Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer adiponectin receptor [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expres
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The apoptosis promoting Bcl family includes
2024-06-04
The apoptosis-promoting Bcl-2 family includes BH3-only proteins (e.g., Bim, Bid and Bad) and multiple-domain proteins (e.g., Bax and Bak). At the time of apoptosis stimulation (e.g., DNA damage), only the BH3-only protein is activated, directly or indirectly promoting Bax/Bak oligomerization, changi
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Serum concentrations of APP and
2024-06-04
Serum concentrations of APP and antioxidants of the 10 queens with pyometra before surgery (T0), at day two (T1) and at day 10 (T2) after ovariohysterectomy are presented in Fig. 1. Concentrations of SAA and Hp were significantly lower (P Discussion Acute phase protein responses were already desc
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Weak and transient interactions of HMGB proteins
2024-06-04
Weak and transient interactions of HMGB proteins in such hit-and-run mechanisms are understandable given that “fluorescence loss in photobleaching” (FLIP) experiments employing GFP-labeled HMGBs have shown that in living cells they are the most mobile of all nuclear proteins [144]. The entire pool o
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Wiskostatin It has been proposed that a PrP
2024-06-04
It has been proposed that a PrP pathogenic mechanism is a toxic gain of function secondary to the misfolding of mutated PrP. However, such a mechanism might not apply to all mutant PrP species, since some mutations had little effect on the stability and folding kinetics of PrP (Swietnicki et al., 19
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At Johns Hopkins Aramco Health JHAH
2024-06-04
At Johns Hopkins Aramco Health (JHAH), we started an ASP in 2011 with an educational program of physicians and pharmacist. The program was enhanced mid-2012 with the following interventions: a re-designed antibiotic sensitivity report [2], intravenous to oral conversion program, vancomycin pharmacok
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The most common grade AEs associated with the soluble fusion
2024-06-04
The most common grade 3/4 AEs associated with the soluble fusion protein ziv-aflibercept are neutropenia, hypertension, and diarrhea [63]. In general, medical oncologists associate ziv-aflibercept with worse toxicity than BV, and meta-analyses of clinical trial data with ziv-aflibercept or BV suppor
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In addition enhanced AT receptor function
2024-06-04
In addition, enhanced AT1 receptor function abnormally increases central and sympathetic activity, contributing to cardiac and renal disease, which in turn alters homeostasis, increases vulnerability to stress, and further injures the brain, and that AT1 receptor blockade ameliorates excessive sympa
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Histochemical analyses using antibody or
2024-06-04
Histochemical analyses using antibody or cDNA probes reveal the precise cellular location of the 12S-lipoxygenases in tissues of interest. An immunohistochemical study in various rat tissues showed specific expression of the leukocyte-type 12S-lipoxygenase in macrophages in lung and spleen [27]. In
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The reactions and the control mechanisms described are all
2024-06-03
The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of epibatidine cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of gl
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br Experimental section br Introduction Microglia were disco
2024-06-03
Experimental section Introduction Microglia were discovered as a novel cell population in Bisindolylmaleimide IV australia in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal out
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It was recently shown that AHR and HIF cooperate to
2024-06-03
It was recently shown that AHR and HIF-1α cooperate to support the metabolism of Tr1 MRS 1220 [6]. Interestingly, AHR and HIF-1α act sequentially to orchestrate the metabolic remodeling of lymphocytes. While HIF-1α regulates the early metabolic reprogramming of Tr1 cells, AHR takes over at later tim
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The finding that OCT is
2024-06-03
The finding that OCT3 is expressed in the nucleus accumbens (Gasser et al., 2009) suggests that inhibition of this transporter may underlie previously described effects of glucocorticoids on extracellular DA concentrations and indicates that DA clearance in this region is not mediated exclusively by
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