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Docking experiments showed that Me MeGlcA
2021-04-02
Docking experiments showed that Me-MeGlcA3Xyl4 and MeGlc3Xyl4 were bound to EcXyn30A and the R293A variant in the same way as MeGlcA3Xyl4, having MeGlcA or its modified forms accommodated in the -2b subsite. All ligands were coordinated by the same MLN 2480 and no new interactions were observed. Th
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The best characterized APC C substrates are recruited via va
2021-04-02
The best-characterized APC/C substrates are recruited via various linear motifs (e.g., D boxes, KEN boxes, and ABBA motifs) that serve as degrons, binding to distinct regions of the β-propeller domain of a coactivator (Figure 1, Figure 3B) (reviewed in [44]). In addition, D boxes also simultaneously
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br Transparency document br Main
2021-04-02
Transparency document Main Text The centrosome is a non-membrane-bound organelle found in most animal cells. It has several important functions, including control of cilia formation, microtubule organization and nucleation, spindle assembly and transport of organelles and vesicles. Centrosomes
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Epinephrine HCl sale br Materials and methods br
2021-04-02
Materials and methods Results Discussion The present study shows that 1) overexpression of wild-type or mutant α-SYN interferes with forskolin-induced DBH up-regulation, 2) α-SYN enters into the nucleus and is able to bind to CRE region, compete for CREB, and attenuate CRE-mediated transcri
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During germ cell development in mouse de novo Dnmts
2021-04-02
During germ cell development in mouse, de novo Dnmts regulate the genomic imprinting and silence of repeat elements. Dnmt3A methylated H19, Dlk1/Gtl2, and Sine B1, whereas Dnmt3B methylated microsatellite repeat elements, the two Dnmts co-methylatedRasgrf1, IAP, and Line1 repeat elements (Lucifero
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We also discovered important clues to domain
2021-04-02
We also discovered important clues to domain AM251 of DGKs and how to exploit these regions for development of DGKα-selective inhibitors. The identification of a probe-modified site at the C1 domain provided the first evidence of a ligand binding site remote from the ATP binding region of DGKs. Alt
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br Concluding Remarks Synthetic cytokine biology has become
2021-04-02
Concluding Remarks Synthetic cytokine biology has become an important research area with novel solutions and ideas for therapeutic approaches, for example, synthekines, fusokines, immunocytokines, neoleukins, MESA receptors, or synthetic Notch or cytokine receptors. In addition to their huge impa
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For the first time the
2021-04-02
For the first time, the V. carinata transcriptome was analyzed and its transcript coding sequences comprehensively characterized. The non-redundant contigs encoding putative CysPs were identified and their 58 4 australia patterns in different tissues were investigated. Our study show that four prot
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Unlike previous studies examining COMT
2021-04-02
Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT Adenosine 5-monophosphate was associated with
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A comparison between tinnitus and controls subjects showed
2021-04-02
A comparison between tinnitus and controls subjects showed increased activity in the left AUD and PHC for the gamma frequency band. The link between gamma band activity in the AUD and tinnitus has been identified using both EEG (van der Loo et al., 2009) and MEG (Weisz et al., 2005, 2007). This is s
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Caspi et al first identified that
2021-04-02
Caspi et al. (2005) first identified that the COMT polymorphism moderated the influence of adolescent cannabis use on developing adult psychosis (Caspi et al., 2005). In particular, compared to Met carriers, subjects with the Val/Val genotype were most likely to exhibit psychotic symptoms and to dev
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The selective estrogen receptor modulators SERMs are another
2021-04-01
The selective estrogen receptor modulators (SERMs) are another type of estrogen receptor ligands. The main difference between SERMs and xenoestrogens relies on the fact that SERMs present functional duality and are able to act both as agonists and antagonists of the estrogen receptors in different t
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It has previously been shown that human melanocytes are resp
2021-04-01
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Liraglutide on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that th
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br Introduction Hydrogen sulfide H S and nitric oxide
2021-04-01
Introduction Hydrogen sulfide (H2S) and nitric oxide (NO) are important gasotransmitters in the cardiovascular system and instrumental to the fine control of vascular tone [1] and cellular function [2]. NO is synthesized from l-arginine by calmodulin-dependent endothelial nitric oxide synthase (e
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In general we observed that the enolase gene
2021-04-01
In general, we observed that the enolase gene with highest mRNA levels was TVAG_043500, under all three iron concentration conditions. mRNA levels for this gene are very similar in normal and iron rich cultures (73.9 and 78.1 fold change, respectively), and higher in iron depleted cultures (118.3 fo
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