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Aldehyde dehydrogenase has been characterized as a cancer st
2021-05-06
Aldehyde dehydrogenase has been characterized as a cancer stem cell marker, which plays a key role in various biological processes in tumor, including cell proliferation, invasiveness and chemoresistance. Recent data of Abourbih et al reported that ALDH1 expression did not correlate with primary tum
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Due to cell cell interactions high concentrations
2021-05-05
Due to cell-cell interactions, high concentrations of LTs can be locally generated in a short period of time during an inflammatory response, thus potentiating LT function. The cellular communication can be mediated between immune cells as well as between immune cells other cell types. Several studi
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Previous studies from our laboratory
2021-05-05
Previous studies from our laboratory have demonstrated that CysLT1R mRNA and protein expression can be upregulated by T2-type cytokines (IL-13, IL-4, and IL-5) in monocytes, macrophages, and eosinophilic HL-60 cells., To our knowledge, however, there are no studies on interactions of cytokines (suc
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Sodium Picosulfate br Results br Discussion SDF performs ess
2021-05-05
Results Discussion SDF-1 performs essential roles in cell migration and proliferation, acts as neuromodulator; and is also involved in many pathological processes including human immunodeficiency virus infection, metastatic malignancy, and chronic inflammatory disorders (Feng et al., 1996, Li
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The cholinergic system has been shown
2021-05-05
The cholinergic system has been shown to play a role in regulation of the inflammatory response [13] as well as in the influence of the metabolism of PCa cells [14]. The reduced activity of cholinesterase (ChoE) and the consequent increased amount of am 580 receptor has been shown to lead to a chol
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Cell swelling stimulates the release of certain amino acids
2021-05-05
Cell swelling stimulates the release of certain amino acids, in particular the non-protein amino LDC000067 australia taurine, via a pathway which has the characteristics of a channel rather than a carrier [54], [69]. Indeed, on the basis of pharmacological inhibition, it was suggested that volume-a
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br Conflicts of interest br
2021-05-05
Conflicts of interest Author contributions Acknowledgements This work was supported by the University of Brescia (ex 60%) and Siderurgica Leonessa research funds to AF. RR was supported by Associazione Italiana per la Ricerca sul Cancro - AIRC (MFAG 18459 grant). We are grateful to Umberto
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moles to grams calculator Epac proteins consist of a carboxy
2021-05-05
Epac proteins consist of a carboxyl-terminal catalytic region and an amino-terminal regulatory region, which harbors one cAMP-binding domain in Epac1 and two in Epac2 [22], [32], [51]. In the absence of cAMP, the regulatory region covers the CDC25-homology domain and autoinhibits Epac's enzymatic ac
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br Materials and methods br Results br
2021-05-05
Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic nrf2 activator induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status
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TgTCEA from petals TgTCEA and TgTCEB from pollen grains TgTC
2021-05-05
TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant enzymes were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as described
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The UPR is composed of
2021-05-05
The UPR is composed of three different pathways that fall under the control of three respective ER transmembrane proteins: PERK, IRE1α (inositol-requiring enzyme 1α) and ATF6 (activating transcription factor 6). As a starting signal for the UPR, misfolded proteins induce the release of GRP78 from th
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Next we evaluated neutralization of Jc Jc
2021-05-05
Next, we evaluated neutralization of Jc1, Jc1-N534A, Jc1-ΔHVR1 and Jc1-ΔHVR1-N534A by sera from individuals chronically infected with HCV GT1 and GT2 (Fig. 4A-C). Like the results of neutralization with monoclonal rho kinase inhibitors and CD81-LEL (Fig. 3), the sera poorly neutralized Jc1. Neutral
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caged compounds br Molecular modeling simulation study Molec
2021-05-05
Molecular modeling simulation study Molecular modeling study was performed through docking of the test compounds into the binding site of hDHFR enzyme using Discovery Studio 2.5 software. Computational docking is an algorithm designed to determine the suitable position and the orientation of the
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G DH has gained interest because of its
2021-05-05
G3DH has gained interest because of its broad substrate specificity and site-selective oxidation properties [9,10]. The conversion product, 3-ketoglycoside, possesses potential as a starting material for the chemical industry such as in polymer and surfactants because the keto group becomes a specif
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CaneCPI showed strong inhibitory activity
2021-05-05
CaneCPI-4 showed strong inhibitory activity against recombinant falcipain-2 and falcipain-3, with IC values of 11.9±0.4nM and 42.3±0.8nM, respectively (Table 1, Supplementary material). Falcipains are involved in hemoglobin cleavage, with generation of two fractions: the heme and the globin. The hem
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