• Despite the central role of mitochondria in

  2021-09-14

  

  Despite the central role of mitochondria in oxidative metabolism, it remains unclear whether mitochondria play a central role in ferroptosis. Supporting this possibility, ferroptosis is associated with dramatic morphological changes of mitochondria, including mitochondrial fragmentation and cristae

• In addition the interplay of membrane curvature induced tens

  2021-09-14

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and histone demethylase induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant f

• In conclusion studies of the regulation of the HO BVR

  2021-09-14

  

  In conclusion, studies of the regulation of the HO-1/BVR/CO pathway by selective pharmacological approaches may lead to the discovery of novel compounds for the treatment of diverse diseases. Recent results validate the use of advances in targeting HO-1 in various vascular diseases. However, there

• The central region of Azalanstat

  2021-09-14

  

  The central region of Azalanstat can be substituted with connecting alkyl chains of different nature and length. Interesting results were given by compounds with a four or five YK-4-279 sale chain, incorporating heteroatoms, such as oxygen (Fig. 2, compound 4) or sulfur, and different functional gro

• Cortisol is a natural glucocorticoid hormone produced by the

  2021-09-14

  

  Cortisol is a natural glucocorticoid hormone produced by the adrenal cortex. Its secretion is stimulated by the sympathetic nervous system, and its main function is to mobilize energy to protect the homeostasis of vital biochemical processes during physical and psychological stress [14]. Chronic lev

• br Conclusion Until recently astrocytes were

  2021-09-14

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of LGX818 homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particular, glial

• br According to WHO estimates diabetes continues to present

  2021-09-14

  

  According to WHO 2014 estimates, diabetes continues to present an increasing health risk to the global population, affecting 422 million individuals worldwide. Type 2 diabetes (T2D), which affects the vast majority (ca. 90%) of the diabetic population, occurs when the body cannot effectively utili

• LOXO-101 These and other observations presented in the elega

  2021-09-13

  

  These and other observations presented in the elegant, rigorous study by Thomas et al. (2018) clarify a puzzling enigma regarding the Rab specificities of yeast TRAPP complexes and further highlight an important though under-appreciated role for the C-terminal HVD of Rabs in GEF substrate selection.

• DNA methylation is a kind of epigenetic modifications that c

  2021-09-13

  

  DNA methylation is a kind of epigenetic modifications that can be described as a heritable alteration in gene expression, without any changes in the DNA sequence. Recent evidences suggest that the regulation of DNA methylation status is a frequent and early event in prostate carcinogenesis. For exam

• Lean mass is representative of

  2021-09-13

  

  Lean mass is representative of the muscle tissue mass equivalent of all the body parts containing water, excluding fat, bone minerals, and such substances which do not contribute to the NMR signal, such as hair, claws, etc. (ECHO-MRI (Houston, TX) user's manual). It was interesting that in the Bob-C

• The differential tissue and ligand dependent signaling descr

  2021-09-13

  

  The differential tissue- and ligand-dependent signaling described here has important implications for the therapeutic potential of synthetic GPR109A agonists for the treatment of atherosclerosis. The failure of MK-0354, a biased, partial GPR109A agonist, to activate signaling pathways upstream of va

• ICH induced striatal lesion produced a reduction of EAAT

  2021-09-13

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino dpn transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (Rao et

• High energy adjusted free glutamate

  2021-09-13

  

  High energy-adjusted free glutamate intake among adults with high education level (above college) or high poverty income ratio (≥3.50) might be a consequence of the difference in intake of some foods such as vegetables and fruits, reflecting upon their socioeconomic status. Previous studies have sho

• br A myriad of receptors in WM To complicate

  2021-09-13

  

  A myriad of receptors in WM To complicate the picture, WM glia express numerous non-glutamatergic neurotransmitter receptors, a fact that is often underappreciated when considering pathophysiology. When examined in isolated optic nerve, a central WM tract completely devoid of neuronal synapses, r

• br Declarations of interest br Acknowledgements This work wa

  2021-09-13

  

  Declarations of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81673321, 21506099), the State Key Laboratory of Drug Research (SIMM1705KF-13), the Natural Science Foundation of Jiangsu Province (Grant No. BK20151541), and the Jiangsu Syne

15685 records 548/1046 page Previous Next First page 上5页 546547548549550 下5页 Last page