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Of the patients that presented a CD dip
2021-11-06
Of the 11 patients that presented a CD4 dip with no cause identified other than HIV-infection, 9 had CD4 counts >200 cells/μL in the next measurement and all experienced the event during the first 24 months of follow-up. Intra-laboratory measurements and individual patient physiologic factors also i
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A high throughput screening campaign
2021-11-06
A high-throughput screening campaign of the Lilly corporate compound collection led to the discovery of as potent and selective inhibitor of GlyT1 (IC=45nM, GlyT2 IC>30,000nM). In addition to the characteristic -methyl glycine moiety as acidic head group and the novel ethanolamine linker, also con
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In response to oxidative stress in DM antioxidant defence
2021-11-06
In response to oxidative stress in DM, antioxidant defence systems are activated in β-cells. Glutathione (GSH) is one of the most abundant antioxidants and has been shown to be expressed at lower concentrations in patients with DM [12], [13]. Furthermore, plasma levels of glycine, which is a synthet
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br Spatial working memory is GluR A dependent The radial
2021-11-06
Spatial working memory is GluR-A-dependent The radial maze task also allowed us to study hippocampus-dependent spatial working memory. On spatial working memory tasks, the correct spatial response that the animal must make varies from trial to trial and is dependent on some conditional, trial-spe
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In mammals the primary cilium is
2021-11-06
In mammals, the primary cilium is considered a hub for signal transduction. The cilium has previous been associated with transduction of several pathways including Wnt (Corbit et al., 2008, McDermott et al., 2010, Tran et al., 2014), PDGF (Clement et al., 2013, Schneider et al., 2010, Schneider et a
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br Genetic manipulation variation of the ghrelin
2021-11-06
Genetic manipulation/variation of the ghrelin system and alcohol-related outcomes Genetic manipulation of the ghrelin system (either the peptide or the receptor gene) via knockout rodent models has provided further insight into the role of this system in alcohol seeking and consummatory behaviors
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DuP 753 mg br Materials and methods br Results Bgal from
2021-11-06
Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino DuP 753 mg residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as other additional a
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Ru II complexes have been reported to be both
2021-11-06
Ru(II) complexes have been reported to be both duplex and G-quadruplex structure stabilizers, and potent anticancer agents [[11], [12], [13], [14]]. Barton, Norden, as well as Ji groups have provided detailed information about recognition and reactions of classical duplex DNA by Ru complexes [[47],
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Two types of processes intrinsic and extrinsic contribute
2021-11-06
Two types of processes, intrinsic and extrinsic, contribute synergistically to the age-related change on structural integrity and physiological function of the skin (Farage, Miller, Elsner, & Maibach, 2008). Intrinsic aging arise from genetically programmed cell aging, normal metabolic activities, a
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In soft agar colony formation assay
2021-11-06
In soft agar colony formation assay, transformed crth2 antagonist indicate anchorage-independent growth and colony formation without attachment on the bottom of cell culture plate. This assay can investigate transformation and tumorigenic activities [24]. Our recent study showed that the long-term
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The results of our analysis of Fas alleles
2021-11-06
The results of our analysis of Fas alleles, Fas 670 A>G, FasL alleles, and FasL IVS2nt 124 A>G for cases and controls are shown in Table 2. For Fas 670, we found statistically significant differences between the two groups regarding the AA rxr receptor (P=0.040) and GG/AG (P=0.040) as well as the A
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Over decades a deeper understanding of terpene synthases has
2021-11-06
Over decades, a deeper understanding of terpene synthases has also permitted enzyme engineering for unnatural substrate acceptance. Novel terpenoids have been successfully synthesized from substrate analogues as by-products from mechanistic investigation (Faraldos et al., 2012; Miller, Yu, & Alleman
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Recent efforts have also tried to identify cancer
2021-11-06
Recent efforts have also tried to identify cancer subsets that are exquisitely responsive to EZH2i apart from those bearing EZH2 gene mutation (Knutson et al., 2012). The dysfunction of SWI-SNF complex, a chromatin-remodeling regulator that partially antagonizes the catalytic function of PRC2 comple
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br Acknowledgement This research was supported
2021-11-06
Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2016R1A2B4012818). Oral Angiotensin Fragment 1-7 acetate is the most popular administration route du
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As for hMOF inhibitor s study Dekker
2021-11-06
As for hMOF inhibitor's study, Dekker and Zheng et al. synthesized MG149 (Fig. 1) as an inhibitor of Tip60 and MOF which has an IC50 value of 74 ± 20 μM and 47 ± 14 μM [31]. However, MG149 has no experimental data on hMOF in cell or in vivo. The lack of hMOF inhibitor limits the function study of hM
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