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This study has some limitations
2022-06-24
This study has some limitations. The RDS technique was not effective for the population of MSM from Natal, as it has not reached the sample size initially calculated. Few seeds had enough waves to disperse the sample and make it closer to a probabilistic sample, even with all efforts from the resear
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The translational relevance of our findings remains uncertai
2022-06-23
The translational relevance of our findings remains uncertain at this point. On the one hand, there have been reports to suggest that boosting KDM4 activity may engender beneficial effects in vivo. For instance, Li et al. have show that KDM4 interacts with β-catenin to mediate Wnt signaling in hepat
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The obtained sequence was deposited in GenBank under accessi
2022-06-23
The obtained sequence was deposited in GenBank under accession number MG703576; it showed a 99% identify with sample HE817764, reported as Demodex cornei, and with JF784000, reported as D. canis. Molecular and phylogenetic analyses and the morphological characteristics helped to rule out D. cornei.
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bromhexine br Financial support This study was
2022-06-23
Financial support This study was supported by Grant PH-102-PP-11, PH-103-PP-11 from the National Health Research Institutes, Taiwan. Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details. Authors’ contributions Acknowledgements Introduction
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br Acknowledgements br Introduction The glutathione S transf
2022-06-23
Acknowledgements Introduction The glutathione S-transferase (GST, EC 2.5.1.18) family of multifunctional enzymes plays a particularly important role in cellular detoxification [1]. Over-expression of the GSTP1 isoform characterizes many human tumor cell lines derived from stomach, brain and co
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While a role for YAP
2022-06-23
While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these Emodin are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manner. Platin
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Introduction Gestational diabetes mellitus GDM is one
2022-06-23
Introduction Gestational diabetes mellitus (GDM) is one of the most common complications associated with pregnancy [1]. Approximately 7.6% of pregnancies in the United States are complicated by GDM [2,3], which significantly increases the mother's risk of developing type 2 diabetes (T2D) later in l
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Acknowledgments This research was supported by the
2022-06-23
Acknowledgments This research was supported by the Korea Research Institute of Chemical Technology (KRICT) funded by the Ministry of Science, ICT & Future Planning (KK1703-G00, KK1707-C05, SI1707-02, KK-1607-C09, and SKO1707C05) and a grant of the Korea Health Technology R&D Project through the Kor
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wst-1 The HRTOF MS of showed a quasi molecular ion peak
2022-06-23
The HRTOF-MS of showed a quasi-molecular ion peak at / 525.3044 [M+Na], corresponding to a quasi-molecular formula of CHNONa (Calcd for CHNONa: 525.3053). IR absorptions at 1680 and 1522cm suggested the presence of amide functions. Based on an analysis of 1D and 2D NMR spectra, the presence of one
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It is considered that activations of MMP and MMP are
2022-06-22
It is considered that activations of MMP-2 and MMP-9 are closely related to progression process of cancer cells, such as invasion and metastasis [22], [23]. In fibrosarcoma cells, GPR40 suppressed not only MMP-2 and MMP-9 activations, but also cell motile and invasive activities, suggesting GPR40 ne
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Vincristine receptor br Introduction For decades regulated a
2022-06-22
Introduction For decades, regulated apoptosis and unregulated, accidental necrosis have been considered as the two sole cell death routes in multicellular organisms. With the beginning of the 21st century a paradigm shift has been witnessed by researchers in the field with the recognition that ma
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The product chain length determination mechanism of prenyltr
2022-06-22
The product chain-length determination mechanism of -prenyltransferases has not yet been elucidated, although mutational analyses of highly conserved residues and of characteristic amino TNF-alpha, recombinant human protein residues in each subfamily of -prenyltransferases have enabled the understa
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A species specific diverse number
2022-06-22
A species-specific diverse number of FPPS genes are present in insect genomes (Zhang and Li, 2008, Cusson et al., 2006). The genome of the yellow fever mosquito Aedes aegypti contains a single FPPS gene (AaFPPS) that is highly expressed in the CA (Nouzova et al., 2011). FPPS catalytic activity in th
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During the activation of the coagulation
2022-06-22
During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium HC-030031 on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directly inhibit plate
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br Role of funding source br Conflict of
2022-06-22
Role of funding source Conflict of interest Acknowledgements We thank F. Blaskovits and P. Kesner for technical assistance. This project was supported by operating grants from the Canadian Institutes of Health Research (CIHR) to X. Zhang (MOP123249) and the National Natural Science Foundati
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