• br Experimental section br Introduction

  2024-07-04

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of all-trans Retinal regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the r

• br Materials and methods br Results br Discussion Several ma

  2024-07-04

  

  Materials and methods Results Discussion Several major signaling and developmental pathways (e.g. EGFR, ALK, KRAS, TGFβ, Notch and Wnt/β-catenin) have been shown to be involved in lung carcinogenesis and they are being exploited as targets of the non-small cell lung cancer therapy (for revi

• Although the mechanisms of APP secretion

  2024-07-04

  

  Although the mechanisms of APP secretion are well characterised (for review see Ref. [1]), production of soluble AChE species is less well understood although we have reported that a metalloproteinase can shed AChE similarly to APP [16], [17]. Recently it has also been demonstrated that cellular pre

• These results must also be addressed in light of porcine

  2024-07-03

  

  These results must also be addressed in light of porcine AMPKγ3R200Q (RN−) mutation. Pigs harboring this mutation produce meat with an abnormally low ultimate pH (pHas 5-Ethynyl-2'-deoxyuridine meat (Copenhafer et al., 2006, Lundström et al., 1998, Milan et al., 2000). This extremely low pH is very

• Apoptozole br Results br Discussion Although the

  2024-07-03

  

  Results Discussion Although the value of ID specialists in the USA has already been described in the literature, this study suggests that the same holds true for the Japanese healthcare environment [7], [17], [18], [19]. Valerio et al. reported that antifungal use in DDD decreased from 66.4 pe

• br Experimental section br Acknowledgements This work was fu

  2024-07-03

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• br Results br Discussion Using primarily an electrophysiolog

  2024-07-03

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• br Regulation of BCAA catabolism The BCAA catabolic

  2024-07-03

  

  Regulation of BCAA catabolism The BCAA catabolic system is equipped in mammalian cells to dispose of excess BCAAs, presumably resulting in relatively stable concentrations of BCAAs in blood and tissues in humans. The main BCAA catabolic pathway is localized in the mitochondria of all tissues. The

• It has been reported that NLRP product caspase

  2024-07-03

  

  It has been reported that NLRP3 product, caspase-1, is increased in the brains of AD patients and experimental AD animals. NLRP3- and caspase-1-deficient animals are resistant to experimental development of AD, and have decreased IL-1β production and significantly increased Aβ clearance (Heneka et a

• br Disclosure br Acknowledgments br Introduction Deeper unde

  2024-07-03

  

  Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small Cell Cycle Compound Library receptor that target genetic mutations known to play critical roles in the progression to metastatic diseas

• br Introduction Diabetes mellitus DM

  2024-07-03

  

  Introduction Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated levels of glucose in the blood. Type 1 diabetes is characterized by insufficient insulin production and needs a daily administration of insulin. Actually, no prevention is known for Type 1 diabetes. Type

• br Materials and methods br Results br

  2024-07-03

  

  Materials and methods Results Discussion Competing financial interests Acknowledgements The work was partially supported by grants from the National Natural Science Foundation of China (Grant no. 31530053 and 31401424) and National Science and Technology Support Plan (Grant no. 2013BA

• br ABCA is a sterol

  2024-07-03

  

  ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl

• Synthesis pharmacological evaluation for the binding at hA h

  2024-07-02

  

  Synthesis, pharmacological evaluation for the binding at hA, hA and hA ARs, and efficacy at hA subtype of the synthesized compounds, together with the assessment of their theoretical ADME properties were the guidelines in this preliminary drug discovery investigation. The synthetic pathways which y

• br Perspectives Given the complexity of the cellular interac

  2024-07-02

  

  Perspectives Given the complexity of the cellular interactome and of protein scaffolding, further progress in revealing how individual membrane proteins, including APP and AChE, interact with each other at various levels, from cell-surface shedding to gene regulation, will clarify some intrinsic

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