• proteasome inhibitor br Size Stability and Toxicity A substa

  2018-10-23

  

  Size, Stability, and Toxicity A substantial number of investigations aiming to unravel the mechanism of the disease have accepted an intermediate structure of aggregated Aβ which is formed earlier than plaques and has been linked to the pathogenesis (Kayed and Lasagna-Reeves, 2013; Klein, 2013; H

• Structure based drug design targeting the well defined

  2018-10-23

  

  Structure-based drug design targeting the well-defined interface (Cherepanov et al., 2005) between the IBD and the HIV-1 IN catalytic core resulted in the development of 2-(quinolin-3-yl)acetic glutathione s-transferase derivatives that inhibit HIV-1 replication (Christ et al., 2010). This novel cl

• aconitine Because of our previous failure

  2018-10-23

  

  Because of our previous failure to find an association of graft failure with pretransplant DSA that exclusively reacted in the exquisitely sensitive SAB assay (Susal et al., 2011), we focused in the present study on pretransplant sera containing CDC- or ELISA-reactive antibodies, selected without re

• A final model is presented to

  2018-10-23

  

  A final model is presented to suggest that the altered microbial composition of the -infected bile duct may promote tumor development. Specifically, the authors propose that infection and colonization of bile ducts with fosters a carcinogenic microenvironment through bacterial metabolic activity, su

• meclizine hcl NO is implicated in various other

  2018-10-23

  

  NO is implicated in various other pathological conditions in the brain, including excitotoxicity during ischemic meclizine hcl injury (Nakamura et al., 2013; Pacher et al., 2007). For instance, in the middle cerebral artery occlusion model, the brain injury is milder in mice treated with an nNOS-sp

• 5-aminolevulinic acid The in vivo replication kinetics of

  2018-10-23

  

  The in vivo replication kinetics of ZIKV in natural human infections remains elusive. The neurotropic nature of ZIKV has been evidenced by mouse experiments (Cugola et al., 2016) and clinical investigations (Carteaux et al., 2016). Our necropsy data from two animals demonstrate that the contemporary

• Even though it has been suggested

  2018-10-23

  

  Even though it has been suggested that the glial scar has inhibitory effects on self-repair and neuroregeneration after SCI, recent studies showed that astrocytes, ependymal and inflammatory somatostatin agonist have also pro-regenerative properties (Anderson et al., 2016; Barnabe-Heider et al., 20

• Our system biology approach was key to reveal a genome

  2018-10-23

  

  Our system biology approach was key to reveal a genome-scale link between central and peripheral gene regulation as studied in circulating leukocytes in response to TBI. We chose to examine the genomics of blood leukocytes since they are abundant in the circulation and have been lately found to serv

• The aim of this study was to

  2018-10-23

  

  The aim of this study was to investigate the impact of therapeutic doses of metformin on uterine mst2 and reproductive function, including implantation and pregnancy, under conditions of hyperandrogenism and insulin resistance. We used a rat model in which PCOS-like features can be induced by a comb

• br Materials and Methods br Results

  2018-10-23

  

  Materials and Methods Results Discussion Multidrug-resistant bacteria are a significant cause of sepsis, the most common cause of death in hospitalized patients, with an annual incidence of 1 million cases and 200,000 deaths in the U.S. alone (Deutschman and Tracey, 2014). This dire perspec

• Findings from the most recent

  2018-10-23

  

  Findings from the most recent Global Burden of Disease study, published in October 2016 in , show that in 2015, the mean life expectancy worldwide had reached roughly 72years. This is an increase of 10years since 2000, largely attributed to improvements in childbirth-associated and infant mortality,

• Our data indicated that CRP may be associated

  2018-10-23

  

  Our data indicated that CRP may be associated with tissue lesions. In addition to hepatic synthesis (Pfafflin and Schleicher, 2009), CRP can be synthesized by lung rotenone (e.g. epithelial cells, lymphocytes) (Ramage et al., 2004; Marc et al., 2004). However, local production in extrahepatic synth

• br Microorganism cultivation and secretome extraction The fu

  2018-10-23

  

  Microorganism cultivation and secretome extraction The fungal isolates belonging to Aspergillus sp. isolated, identified and labeled as A. fumigatus LF9 was used in this study [3]. DNA sequence of this isolate is available in GenBank under accession no. JF815073. A. fumigatus LF9 was cultivated a

• br Data sets and attributes The data published here are

  2018-10-23

  

  Data sets and attributes The data published here are organized in two ‘csv’ files, ‘rawdata.csv.gz’ (4.5MB) and ‘features.csv’ (200kB). The raw data are stored in the first file ‘rawdata.csv.gz’, where each line represents a single measurement per sensor. Consequently, one needs to read specific

• The study contributes to define the strategies to reach

  2018-10-23

  

  The study contributes to define the strategies to reach high performance Micafungin buildings for Mediterranean climate according with the national requirements. The reduction of CO2 gas emissions, primary energy consumptions and costs have been obtained for several solutions compared to the referen

16065 records 1068/1071 page Previous Next First page 上5页 10661067106810691070 下5页 Last page