• Natural arising autoantibodies to oxidation associated epito

  2018-11-05

  

  Natural arising autoantibodies to oxidation-associated epitopes have been shown to modulate the initiation and progression of a range of immune-mediated inflammatory diseases including atherosclerosis. These autoantibodies are postulated to play roles in homeostasis and immune regulation (Gronwall

• pdgf receptor br Limitations Though the use of organ or

  2018-11-05

  

  Limitations Though the use of organ- or tissue-on-a-chip devices shows a great deal of promise for future applications, it is important to remember that these are relatively new technologies and require further advancements prior to widespread use. It is first necessary to characterize these devi

• br There is increasing evidence of the important role of

  2018-11-05

  

  There is increasing evidence of the important role of innate immune system in tumor surveillance (). The spontaneous immune response of T nicergoline against tumors has a powerful prognostic value and can contribute to tumor control in patients. Indeed, T cell-based immunotherapies have shown to

• The following are the supplementary data related to this

  2018-11-05

  

  The following are the supplementary data related to this article. Funding Sources This work is funded by the Medical Research Council (H8RSRS00), Ovarian Cancer Action (HER00070), the Oxford Biomedical Research Centre, the National Institute for Health Research (HJRWAC05) and the Experimental Ca

• Our previous study demonstrated that HDAC

  2018-11-05

  

  Our previous study demonstrated that HDAC inhibition contributed to the anticancer effect of statins (Lin et al., 2008). Combining anti-cancer drugs with different mechanisms is a rational approach to improve efficacy. JMF3086, synthesized to inhibit both HDACs and HMGR, exhibits significant benefit

• The androgen receptor AR is a ligand dependent transcription

  2018-11-05

  

  The androgen receptor (AR) is a ligand-dependent transcriptional factor that belongs to the nuclear receptor superfamily. Androgen/AR signals play important roles in normal liver function and in the development of liver diseases including HCC (Ma et al., 2014). Previous studies revealed a male predo

• Collectively our results clearly indicate that any experimen

  2018-11-05

  

  Collectively, our results clearly indicate that any experiment assessing the effect of laser light on cultured cytokine inhibitors is not representative of the in vivo condition. Indeed, whereas laser light increased cell metabolism and proliferation in cell culture, the overall effect in vivo was

• br Materials and Methods br Results br Discussion Although

  2018-11-05

  

  Materials and Methods Results Discussion Although genome-wide association studies provide a systematic, powerful, and unbiased method for studying the common disease/common variant (CDCV) hypothesis of complex disorders such as schizophrenia, the identification of susceptibility loci for sc

• To determine if the overexpression of miR negatively

  2018-11-05

  

  To determine if the overexpression of miR-137 negatively regulate EFNB2 expression, human neuroblastoma SH-SY5Y cells were transfected with mature miR-137 sequences or negative control miRNAs. The results showed that the overexpression of miR-137 did not affect the mRNA expression of EFNB2 but signi

• br Conclusions br Funding Sources This work is supported

  2018-11-05

  

  Conclusions Funding Sources This work is supported by the Wellcome Trust through a Strategic Award, reference 104036/Z/14/Z. GS:SFHS was funded by a grant from the Scottish Government Health Department, Chief Scientist Office, number CZD/16/6. The authors acknowledge with gratitude the financi

• Small scale systems or POU systems have

  2018-11-05

  

  Small scale systems or POU systems have become the most suitable methods of treatment in the rural areas as it has many advantages. It does not require large volumes of water and is not affected by difficult topography or dispersed settlement. Most small scale systems may not require electricity (So

• Laboratory studies have shown that

  2018-11-05

  

  Laboratory studies have shown that total sleep deprivation for 24–72h impairs the performance of many tasks [1,6,7]. So, it is possible that the lack of sleep may affect a basic cognitive process, such as attention, working memory or executive functions, crucial for the execution of a broad range of

• AMD-070 Herein we report the use of an LPG coated

  2018-11-05

  

  Herein, we report the use of an LPG coated with a poly(allylamine hydrochloride)/SiO2 NPs (PAH/SiO2) film [14,18] for the identification and quality assessment of beverages. Five different types of beverages, red and white wines, brandy, sake (a Japanese rice wine), and shochu (a Japanese distilled

• Autophagy enables cancer cell survival

  2018-11-03

  

  Autophagy enables cancer cell survival by maintaining energy production, which can lead to therapeutic resistance (). Several preclinical studies showed that clinically relevant doses of radiation directly promote autophagy in cancer cells and inhibition of autophagy can restore chemosensitivity and

• Our systematic review demonstrated that the majority

  2018-11-03

  

  Our systematic review demonstrated that the majority of NOD2-smoking studies were underpowered to detect an interaction; for example, 10 identified studies included fewer than 300 participants (de Diego et al., 2006; Giachino et al., 2004; Laghi et al., 2005; Mardini et al., 2005; Mendoza et al., 20

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