• Introduction The stem cell niche is

  2018-10-22

  

  Introduction The stem cell niche is a unique microenvironment that maintains long-term repopulation of a specific tissue by undergoing self-renewal of stem ABT-263 and by producing progenies of increasingly differentiated cells. A large amount of knowledge concerning the regulation of stem cell sel

• In this study we have described methods for the

  2018-10-22

  

  In this study we have described methods for the selective isolation of primitive hMSCs that may prove advantageous both experimentally and therapeutically. The identification of the combination marker LTV makes it possible to prospectively isolate functional hMSCs directly from BM. Using these cells

• mth1 pathway To study the status of DNA

  2018-10-22

  

  To study the status of DNA methylation during cellular reprogramming, we have analyzed the gene expression and methylation profiles of somatic mth1 pathway from three different lineages, representative of different embryonic germ-layers, and the iPSCs derived from them, as well as control human ESCs

• br Results br Discussion br Experimental Procedures br Ackno

  2018-10-22

  

  Results Discussion Experimental Procedures Acknowledgments Introduction The transplantation of dopaminergic (DA) neurons represents one of the potential strategies for the treatment of Parkinson’s disease (PD), and human pluripotent stem lipid metabolism (PSCs) are expected to be a p

• Co culture of CDSCs with USSCs revealed regulation of osteo

  2018-10-22

  

  Co-culture of CDSCs with USSCs revealed regulation of osteo- and chondro-associated markers, from which BMP2, BMP4, PTHLH, ACAN and FOXF1 were upregulated and BSP, RUNX2, SOX9, TWIST1 and MSX2 were downregulated after co-culture (Supplementary Fig. 8). Many different transcription factors and regula

• We recently found that E cad function cannot

  2018-10-22

  

  We recently found that E-cad function cannot be replaced by N-cad during the formation of the trophectoderm, the first polarized epithelium formed during mammalian development. In the blastocyst, the E-cad extracellular domain provides a unique and indispensable survival signal by facilitating Igf1r

• In conclusion a D suspended MC rocker

  2018-10-20

  

  In conclusion, a 3D suspended MC rocker platform, similar to a wave bioreactor, that integrates both hESC expansion and CM differentiation has been developed and shown to be capable of producing the highest quantities of CMs to date (190.5±58.8×106 cTnT positive CM/production run; 31.75±9.74 cTnT po

• The following are the supplementary data related to this

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgments This study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare, and Family Affairs, Republic of Korea (Grant no. A120262) and a 2012 grant (10172KFDA993) from the Korea Food &

• Even though substrate stiffness and tethering is mostly

  2018-10-20

  

  Even though substrate stiffness and tethering is mostly known to affect focal adhesions (Trappmann et al., 2012; Wen et al., 2014; Levental et al., 2009), increasing evidence suggests that it may also affect cadherin-mediated intercellular adhesion (Smutny and Yap, 2010; Ladoux et al., 2010). Substr

• The finding that MHC and myogenin expression does not change

  2018-10-20

  

  The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l

• We would like to thank the Gene

  2018-10-20

  

  We would like to thank the Gene Expression Core Facility in the Department of Pathology at UCLA for array analysis; BSCRC Flow Core staff Jessica Scholes and Felicia Codrea for their help with FACS sorting; Jonathan Carlson for useful discussion; and Jason Ernst for thoughtful comments on the manusc

• Rimonabant br Materials and methods br Acknowledgements We w

  2018-10-20

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

• Western blot analysis revealed undetectable levels of full

  2018-10-20

  

  Western blot analysis revealed undetectable levels of full-length TLE1 protein in TLE1 pituitary adenylate cyclase-activating peptide relative to TLE1 cells (Fig. 1B). These results are consistent with the 1bp insertion in exon 2 leading to disruption of TLE1 expression. Genomic integrity of TLE1 a

• Next to the significant evidence that CpG methylation of the

  2018-10-20

  

  Next to the significant evidence that CpG methylation of the HLA-G promoter is important for the transcriptional activity of the gene (Moreau et al., 2003; Mouillot et al., 2005), HLA-G voltage gated sodium channel is also post-transcriptionally regulated by the 3′UTR. Several polymorphic sites in t

• MAPK Inhibitor Library Another major limitation of the adult

  2018-10-20

  

  Another major limitation of the adult cardiac stem cell field is the inability to get full differentiation from putative stem/progenitor MAPK Inhibitor Library in vitro or in vivo. In fact, although expression of cardiac genes and proteins is demonstrated frequently, the levels, relative to authent

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