• aa utp br Case report A year old male presented to

  2018-11-14

  

  Case report A 58-year-old male presented to the emergency room with sudden-onset aphasia. Neurological examination showed no significant focal neurological deficits other than aphasia. Brain magnetic resonance imaging (MRI) showed a nonenhanced aa utp tumor in the left frontoparietal lobe (Fig. 

• For years FGF has been a requisite

  2018-11-14

  

  For years, FGF has been a requisite component in human pluripotent stem cell media (Chen et al., 2011; Ludwig et al., 2006), and yet the mechanism by which FGF supports pluripotency was unknown. Our data show that ERK2, a downstream effector in the FGF pathway, directly phosphorylates NANOG at Ser52

• Understanding of potential mechanisms involved in the initia

  2018-11-14

  

  Understanding of potential mechanisms involved in the initial inherent neuronal bias of cultures and then using small molecules to alter this bias towards astrocyte lineages will enable uniform and faster processes to generate astrocytes. Here we explore the epigenetic mechanism that maintains the p

• lrrk2 A limited number of studies have

  2018-11-14

  

  A limited number of studies have been conducted on the simultaneous oxidation of different lrrk2 of organochloride compounds and their relative performance with regards to photocatalyst adsorption selectivity. In this study, three structurally dissimilar organochloride compounds will be analysed fo

• These promising laboratory findings and preclinical results

  2018-11-14

  

  These promising laboratory findings and preclinical results inspired the current prospective, randomized, phase I/II clinical trial (, AdiFLAP Trial) designed to evaluate the safety and efficacy of AGTP in patients with chronic myocardial infarction undergoing CABG. Patients were enrolled if they we

• br Funding br Conflict of Interest

  2018-11-14

  

  Funding Conflict of Interest Statement Author Contributions Acknowledgements This work was supported in part by the University of Zurich, Switzerland, and the Federal Office of Public Health, Switzerland. Introduction Conformational diseases, which include Alzheimer\'s disease and

• Ongoing work at developing ligands and modulators of

  2018-11-14

  

  Ongoing work at developing ligands and modulators of PPARγ is focused on harnessing its anti-inflammatory properties. In recent years, some PPARγ agonists with anti–inflammatory effects (pioglitazone, Sitagliptin metformin/rosiglitazone combination) have already completed clinical trials. However, e

• Machine learning is a branch

  2018-11-14

  

  Machine learning is a branch of AI-based methods that we have applied to examine pathophysiological and clinical parameters as well as therapeutic outcomes in the past, whereby it outperformed standard statistical inference with datasets of as little as 28 patients (Chigutsa et al., 2015; Gumbo et a

• Silvestrol The majority of pharmacogenetic studies are perfo

  2018-11-14

  

  The majority of pharmacogenetic studies are performed in Asian and Caucasian populations; data generated in African-American populations are sometimes extrapolated to represent the population of the African continent. However, the ancestry of African-Americans is predominantly from Niger-Kordofanian

• Any intravitreally injected substance must prove efficacy an

  2018-11-14

  

  Any intravitreally injected substance must prove efficacy and safety. While our study was not designed as a preclinical safety study, we did not find any obvious structural changes after Sema3f treatment in either of the two in vivo models, which is not surprising given that Sema3f is physiologicall

• Despite a clear oncogenic role for NFIB

  2018-11-14

  

  Despite a clear oncogenic role for NFIB in SCLC and melanoma, tumour suppressive functions have been demonstrated or strongly suggested in other cancers. Although the molecular mechanisms behind its anti-oncogenic functions are not well understood, the fact that NFIB is widely expressed in multiple

• Oversized preliminary clusters were selected for

  2018-11-14

  

  Oversized preliminary clusters were selected for subsequent splitting by agglomerative hierarchical clustering based on a criterion of (mean number of marked minutiae per examiner) >1.5. This arbitrary threshold was selected because (1) automated splitting of clusters meeting this criterion was high

• Each learning unit included a document

  2018-11-14

  

  Each learning unit included a document describing concepts and skills, a self-assessment questionnaire, and a set of learning activities. Each learning activity contained a document describing the activity, the digital resources and assets needed to complete it, and sample solutions or visual descri

• br Experimental design materials and

  2018-11-14

  

  Experimental design, materials and methods For the potential oral administration, the six experimental liquid formulations of commercial pine-derived phytosterol (CPP) reduced pH to 2 and increased pH again up to 7 to mimic the human digestive system (Yi et al., 2016) [1]. The concentration of β-

• Additional evidence for left hemispheric lateralization in a

  2018-11-14

  

  Additional evidence for left hemispheric lateralization in adults was also reported in a cross-cultural fMR-A study by Holloway et al. (2012). This study revealed a striking hemispheric difference in IPS activation in response to the presentation of Arabic numerals and Chinese ideographs. Two groups

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