• In conclusion a D suspended MC rocker

  2018-10-20

  

  In conclusion, a 3D suspended MC rocker platform, similar to a wave bioreactor, that integrates both hESC expansion and CM differentiation has been developed and shown to be capable of producing the highest quantities of CMs to date (190.5±58.8×106 cTnT positive CM/production run; 31.75±9.74 cTnT po

• The following are the supplementary data related to this

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgments This study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare, and Family Affairs, Republic of Korea (Grant no. A120262) and a 2012 grant (10172KFDA993) from the Korea Food &

• Even though substrate stiffness and tethering is mostly

  2018-10-20

  

  Even though substrate stiffness and tethering is mostly known to affect focal adhesions (Trappmann et al., 2012; Wen et al., 2014; Levental et al., 2009), increasing evidence suggests that it may also affect cadherin-mediated intercellular adhesion (Smutny and Yap, 2010; Ladoux et al., 2010). Substr

• The finding that MHC and myogenin expression does not change

  2018-10-20

  

  The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l

• We would like to thank the Gene

  2018-10-20

  

  We would like to thank the Gene Expression Core Facility in the Department of Pathology at UCLA for array analysis; BSCRC Flow Core staff Jessica Scholes and Felicia Codrea for their help with FACS sorting; Jonathan Carlson for useful discussion; and Jason Ernst for thoughtful comments on the manusc

• Rimonabant br Materials and methods br Acknowledgements We w

  2018-10-20

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

• Western blot analysis revealed undetectable levels of full

  2018-10-20

  

  Western blot analysis revealed undetectable levels of full-length TLE1 protein in TLE1 pituitary adenylate cyclase-activating peptide relative to TLE1 cells (Fig. 1B). These results are consistent with the 1bp insertion in exon 2 leading to disruption of TLE1 expression. Genomic integrity of TLE1 a

• Next to the significant evidence that CpG methylation of the

  2018-10-20

  

  Next to the significant evidence that CpG methylation of the HLA-G promoter is important for the transcriptional activity of the gene (Moreau et al., 2003; Mouillot et al., 2005), HLA-G voltage gated sodium channel is also post-transcriptionally regulated by the 3′UTR. Several polymorphic sites in t

• MAPK Inhibitor Library Another major limitation of the adult

  2018-10-20

  

  Another major limitation of the adult cardiac stem cell field is the inability to get full differentiation from putative stem/progenitor MAPK Inhibitor Library in vitro or in vivo. In fact, although expression of cardiac genes and proteins is demonstrated frequently, the levels, relative to authent

• We propose that a quantitative

  2018-10-20

  

  We propose that a quantitative marker for tracking cardiac myocyte maturation resides in the developmentally controlled and irreversible (excepting targeted reprogramming) genetic switch in the sarcomeric TNNI gene. Owing to strict developmental control in all mammalian hearts, including humans, the

• A variety of suitable murine xenograft models are currently

  2018-10-20

  

  A variety of suitable murine xenograft models are currently used in hematopoietic research, yet these animals require conditioning prior to experimentation. Given the increasingly restricted access to radiation sources, NBSGW mice are broadly enabling, allowing laboratories without access to radiati

• Previous studies have used acute irradiation induced injury

  2018-10-20

  

  Previous studies have used acute irradiation-induced injury models to provide mechanistic insight into the regeneration process, revealing that actively proliferating IESC (active IESC) and slowly proliferating IESC (quiescent IESC) populations occur within the lower regions of the crypt (Barker et 

• Another question to address is the potential influence

  2018-10-20

  

  Another question to address is the potential influence of the degree of maturity of prepubertal donor tissue on the success of transplantation. Donor age-dependent differential gene expression and subsequent protein expression have been reported in tissue grafts. This could alter the initial ability

• br Materials and methods br Acknowledgements This

  2018-10-20

  

  Materials and methods Acknowledgements This work was supported by grants from Instituto de Salud Carlos III (PI 15/000227 to MC, Plataforma en Red de Recursos Biomoleculares y BioinformaticosPRB2 PT13/0001/0042) cofunded by FEDER. Resource table. Resource details Loss-of-function mutation

• br Results br Discussion Two different lineages of BAs

  2018-10-20

  

  Results Discussion Two different lineages of BAs have been known. Classical BAs are derived from Myf-5 expressing common progenitors for myoblasts and BAs (Seale et al., 2008). The myoblastic precursors originate from the mesenchymal stem SEN0014196 (MSCs). PRDM16 is crucially involved in the

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