• br Author Contributions br Acknowledgments This

  2018-10-23

  

  Author Contributions Acknowledgments This work was supported in part by the Canadian Institutes of Health Research (a grant to Q.B.L, #105218, and a New Investigator Award to Q.B.L), the Ontario Ministry of Research and Innovation (an Early Researcher Award to Q.B.L, #112621), and Natural Scie

• Our study shows that the gut

  2018-10-23

  

  Our study shows that the gut microbiota in both genetic and simple obesity share similar structural and functional features of dysbiosis, such as 1) higher production of toxins with known potential to induce metabolic deteriorations such as TMAO and indoxyl sulfate; 2) higher abundance of genomes th

• Past contributions of military medicine to civilian health c

  2018-10-23

  

  Past contributions of military medicine to civilian health care are numerous and substantive. They include improvements in ground and aeromedical medical evacuation (Larrey, 1814; Connor, 2010), regulation (Anon., 1937), open treatment of severe wounds (Moorhead, 1942a, 1942b; Gould, 1917), the comb

• Using an additive model integrated in

  2018-10-23

  

  Using an additive model integrated in the CaTS, we had 80% power for the overall dataset (961 cases and 3260 controls), assuming a minor disease allele frequency of 0.20, a genotypic relative risk for this variant of 1.31, a prevalence of neuropathic pain in the diabetic population of 0.25, and the

• br Acknowledgments br Introduction Sickle cell disease SCD

  2018-10-23

  

  Acknowledgments Introduction Sickle cell disease (SCD) is one of the commonest severe inherited disorders affecting millions of people worldwide (Piel et al., 2013). Complications of the disease arise from the presence in patients\' red cells of the abnormal haemoglobin (Hb), HbS, which has a

• br Diabetic retinopathy and age related macular

  2018-10-23

  

  Diabetic retinopathy and age-related macular degeneration are leading causes of blindness among older adults. Both conditions are more prevalent among those with chronic kidney disease (CKD). However, few if any previous examinations of CKD and visual impairment (VI) have been conducted. This gap

• Mitochondria in which PGAM resides are the largest cellular

  2018-10-23

  

  Mitochondria, in which PGAM5 resides, are the largest cellular direct thrombin inhibitor store, housing OXPHOS proteins for ATP generation and β-oxidation enzymes for fuel delivery. When bodies are exposed to stresses that disrupt energy homeostasis, it is expected that several metabolic challenges

• proteasome inhibitor br Size Stability and Toxicity A substa

  2018-10-23

  

  Size, Stability, and Toxicity A substantial number of investigations aiming to unravel the mechanism of the disease have accepted an intermediate structure of aggregated Aβ which is formed earlier than plaques and has been linked to the pathogenesis (Kayed and Lasagna-Reeves, 2013; Klein, 2013; H

• Structure based drug design targeting the well defined

  2018-10-23

  

  Structure-based drug design targeting the well-defined interface (Cherepanov et al., 2005) between the IBD and the HIV-1 IN catalytic core resulted in the development of 2-(quinolin-3-yl)acetic glutathione s-transferase derivatives that inhibit HIV-1 replication (Christ et al., 2010). This novel cl

• aconitine Because of our previous failure

  2018-10-23

  

  Because of our previous failure to find an association of graft failure with pretransplant DSA that exclusively reacted in the exquisitely sensitive SAB assay (Susal et al., 2011), we focused in the present study on pretransplant sera containing CDC- or ELISA-reactive antibodies, selected without re

• A final model is presented to

  2018-10-23

  

  A final model is presented to suggest that the altered microbial composition of the -infected bile duct may promote tumor development. Specifically, the authors propose that infection and colonization of bile ducts with fosters a carcinogenic microenvironment through bacterial metabolic activity, su

• meclizine hcl NO is implicated in various other

  2018-10-23

  

  NO is implicated in various other pathological conditions in the brain, including excitotoxicity during ischemic meclizine hcl injury (Nakamura et al., 2013; Pacher et al., 2007). For instance, in the middle cerebral artery occlusion model, the brain injury is milder in mice treated with an nNOS-sp

• 5-aminolevulinic acid The in vivo replication kinetics of

  2018-10-23

  

  The in vivo replication kinetics of ZIKV in natural human infections remains elusive. The neurotropic nature of ZIKV has been evidenced by mouse experiments (Cugola et al., 2016) and clinical investigations (Carteaux et al., 2016). Our necropsy data from two animals demonstrate that the contemporary

• Even though it has been suggested

  2018-10-23

  

  Even though it has been suggested that the glial scar has inhibitory effects on self-repair and neuroregeneration after SCI, recent studies showed that astrocytes, ependymal and inflammatory somatostatin agonist have also pro-regenerative properties (Anderson et al., 2016; Barnabe-Heider et al., 20

• Our system biology approach was key to reveal a genome

  2018-10-23

  

  Our system biology approach was key to reveal a genome-scale link between central and peripheral gene regulation as studied in circulating leukocytes in response to TBI. We chose to examine the genomics of blood leukocytes since they are abundant in the circulation and have been lately found to serv

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