• Traditionally testing of hPSC lines for gross chromosomal ch

  2018-10-24

  

  Traditionally, testing of hPSC lines for gross chromosomal changes employed karyology by chromosome banding of metaphase nuciferine (Amps et al., 2011; Baker et al., 2007). Although karyotyping allows examination of the entire cell genome in a single assay, an often overlooked issue in evaluating h

• SAG Overall our data support the view

  2018-10-24

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• A complementary study confirms our findings that GATA is nec

  2018-10-24

  

  A complementary study confirms our findings that GATA6 is necessary for 10058-F4 specification as well as the decreased efficiency of β-like cell generation from the GATA6 PSC line (Shi et al., 2017). This other report did have one major discrepancy with our results; they did not see a defect in gl

• br Methods br Results In there were

  2018-10-24

  

  Methods Results In 1860 there were 1100 counties within the boundaries of states legally permitting slavery (Upper South: 621; Deep South: 479), and in 2010 these same states consisted of 1,347 counties or county equivalents (716 and 624 for the Upper and Deep South, respectively). Spatial int

• However after several decades of

  2018-10-24

  

  However, after several decades of globalisation and neoliberal economic policies, long-term employment contracts and a high level of job security have become less GSK1120212 on the labour market. Instead, precarious work, i.e. short-term contracts, involuntary part time employment, employment throug

• HFI is operationally defined as the lack of access to

  2018-10-24

  

  HFI is operationally defined as the lack of access to food because of financial constraints (Tarasuk, Dachner & Loopstra, 2014) and in Canada is measured through national survey responses to the Household Food Security Survey Module (HFSSM) (Bickel, Nord, Price, Hamilton & Cook, 2000; Health Canada,

• We address this problem from

  2018-10-24

  

  We address this problem from a computational modeling point of view, and build an ABM that simulates the outcomes of different targeting methods including selected realistic factors that may interact. There exists a limited but rapidly developing literature for modeling social influence on obesity p

• A growing body of literature has developed to formally prese

  2018-10-24

  

  A growing body of literature has developed to formally present these assumptions and discuss their implications for policy makers (Harper et al., 2010). In that spirit, the present analysis seeks to show that efforts to improve overall population health may disadvantage some groups; whether equity o

• Finally in column we use the instrumental

  2018-10-23

  

  Finally, in column (5) we use the instrumental variable procedure, using the school inputs as instruments for school proficiency. We perform this exercise to examine whether there are omitted variables that are correlated with the proficiency and with wages, such as the students’ average (cell) abil

• Tivantinib From the Census data we created two dummy variabl

  2018-10-23

  

  From the 2000 Census data we created two dummy variables that identify the educational characteristics of the youths of the 1977 and 1978 cohorts. One of them is a variable on years of study, which identifies the individuals with 12 or more years of schooling (EDUCA_15), equal to 1 for those individ

• Our results provide a fundamental insight into

  2018-10-23

  

  Our results provide a fundamental insight into the nature of primary varicose vein disease. A strong influence of genotypes at MTHFR c.677C>T and c.1298A>C on the morphological specification of primary varicose veins and progression towards complicated disease is suggested. The results provide clues

• We have shown that the gatekeeper valine to methionine

  2018-10-23

  

  We have shown that the gatekeeper valine to methionine substitutions in FGFR1 and FGFR3 resulted in reduction of sensitivity to selective inhibitors PD17307 and AZD4547; two other tested inhibitors, AP24534 and TKI258, retained their efficacy (Figs. 1, 2 and 4, Table 1). While the multi-kinase, type

• br Acknowledgments br Introduction Sarcoidosis

  2018-10-23

  

  Acknowledgments Introduction Sarcoidosis is an inflammatory granulomatous disease of unknown etiology affecting multiple organs, such as the lungs, skin, CNS, and eyes (Costabel, 2001; Costabel and Hunninghake, 1999; Iannuzzi et al., 2007; Hunninghake et al., 1999). Common features shared by p

• br Author Contributions br Acknowledgments This

  2018-10-23

  

  Author Contributions Acknowledgments This work was supported in part by the Canadian Institutes of Health Research (a grant to Q.B.L, #105218, and a New Investigator Award to Q.B.L), the Ontario Ministry of Research and Innovation (an Early Researcher Award to Q.B.L, #112621), and Natural Scie

• Our study shows that the gut

  2018-10-23

  

  Our study shows that the gut microbiota in both genetic and simple obesity share similar structural and functional features of dysbiosis, such as 1) higher production of toxins with known potential to induce metabolic deteriorations such as TMAO and indoxyl sulfate; 2) higher abundance of genomes th

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