• Triglycerides play a central role in the regulation of lipop

  2018-11-06

  

  Triglycerides play a central role in the regulation of lipoprotein interactions to maintain lipid metabolism. These lipids are not directly atherogenic but represent an important marker of atherosclerosis risk [24]. The elevated plasma triglyceride concentrations have been also associated with chole

• br Results and discussion In order

  2018-11-06

  

  Results and discussion In order to validate our results, we analyzed allelic-specific expression of various genes on the X chromosome. We identified heterozygous single nucleotide polymorphisms (SNPs) located within coding regions of X chromosome genes. We then sequenced the complementary DNA (cD

• Guldberg s group Peister et

  2018-11-06

  

  Guldberg\'s group (Peister et al., 2009) demonstrated the potential of AFSCs to produce 3D mineralized bioengineered constructs in vitro and in vivo, suggesting that AFSCs may be an effective cell source for functional repair of large bone defects. In particular, it was shown that: i) in vitro pre-d

• br Materials and methods br Results

  2018-11-06

  

  Materials and methods Results To easily quantify hematopoietic development from human ES cells, we created a fluorescent reporter line. The pan-hematopoietic surface marker, CD43 (leukosialin/SPN), is expressed in all hematopoietic lineages beginning at the hematopoietic progenitor stage durin

• The effects of TLQP on neurogenesis are thus similar to

  2018-11-06

  

  The effects of TLQP-62 on neurogenesis are thus similar to what is reported for antidepressant fluoxetine and serotonin (5-HT), both of which increase the proportion of undetermined Type 2a NPCs marked by Nestin+ and DCX-immunostaining and lacking the radial glial-like morphology (Boku et al., 2011;

• br Conclusions br Author contributions br Author disclosure

  2018-11-06

  

  Conclusions Author contributions Author disclosure statement Acknowledgments The authors wish to thank Dr. Sandrine Humbert for the helpful comments on the manuscript and to Dr. Isabel Nunes for the technical assistance in topotecan experiments. This work was supported by projects PTDC/S

• The following are the supplementary

  2018-11-06

  

  The following are the supplementary data related to this article. Acknowledgment This work was supported by the Ministry of Science and Technology 973 program of China (2011CB504402, 2012CB966802 and 2012CB966304), and the \"Strategic Priority Research Program\" of the Chinese Academy of Science

• To investigate whether PD derived

  2018-11-06

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• The importance of the finding

  2018-11-06

  

  The importance of the finding that the prostaglandin pathway is selectively downregulated by MSX2, but not MSX1, is 2-fold; i) this functional disparity between MSX1 and MSX2 provides a mechanistic insight into a cellularization event during muscle dedifferentiation and ii) it also demonstrates that

• There were discrepancies between the

  2018-11-06

  

  There were discrepancies between the mRNA and protein levels of p63 and K12. It is known that the mRNA level does not always correlate with the protein level. In addition, protein expression rather than mRNA expression dictates the phenotype of the cells. A better correlation was found between the c

• Using the combination of a mitogen activated protein kinase

  2018-11-06

  

  Using the combination of a mitogen-activated protein kinase kinase (MEK) inhibitor, PD0325901 (PD03), and a glycogen synthase kinase 3 (GSK3) inhibitor, CHIR99021 (CHIR), which will hereafter be referred to as 2i, mouse ESCs (mESCs) are maintained in a ground state (Ying et al., 2008). CHIR activate

• Due to the major differences in phenotype between human and

  2018-11-05

  

  Due to the major differences in phenotype between human and murine GATA6 disease models, human pluripotent stem cells (PSCs) offer an alternative system for the in vitro study of GATA6. With recent developments in the genome-editing field, the use of clustered regularly interspaced short palindromic

• Here we identified and characterized MM cell subpopulations

  2018-11-05

  

  Here, we identified and characterized MM cell subpopulations in vitro based on their increased endogenous expression of SOX2 and OCT4 driving a reporter (EGFP) (Hotta et al., 2009; Tang et al., 2015). We demonstrate these angiotensin receptor blockers to have different properties with respect to ch

• When it comes to the development of statistical

  2018-11-05

  

  When it comes to the development of statistical radio engineering and radiophysics, Kotel\'nikov should be given credit where credit is due; we should point out, for historical accuracy, that in his monograph [2] he obtained, among other calculations, an example of a canonical decomposition, even th

• Thus the calculated Navier Stokes equations for an

  2018-11-05

  

  Thus, the calculated Navier–Stokes equations for an incompressible conducting fluid which include the density of the EM field force as the driving force can be expressed in the following way in differential form: Here μ is the effective viscosity, defined as the sum of the laminar and the turbule

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