• In contrast to the normal cells the requirement for

  2018-10-24

  

  In contrast to the normal cells, the requirement for cell:cell contacts to promote survival was removed in the H7 and H14 adapted cells, implying the loss of niche dependence, as has also been reported elsewhere (Werbowetski-Ogilvie et al., 2009). Consequently, the functional significance of the obs

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Induced pluripotent stem Mitiglinide Calcium (iPSCs) have similar properties as embryonic stem cells (ESCs), such as self-renewal and differentiation capacity (Park et al., 2008c; Takahashi and Yamanaka, 2006). Rep

• Monosynaptic tracing using modified rabies virus has

  2018-10-24

  

  Monosynaptic tracing using modified rabies virus has previously been successfully used to trace existing neuronal circuits in vivo (Wall et al., 2013; Watabe-Uchida et al., 2012) and also to map the integration of newborn neurons in the olfactory bulb and hippocampus (Deshpande et al., 2013; Vivar e

• br Results br Discussion Analysis of DNA damage foci

  2018-10-24

  

  Results Discussion Analysis of DNA-damage foci in CHK1i-treated EZ Cap Reagent AG led to the remarkable discovery that CHK1i allowed FA-deficient iPSCs to escape G2 arrest and undergo mitosis without repairing the DSBs that had evidently caused their arrest. A previous study indicates that DS

• The present study indicated that induction of glutamatergic

  2018-10-24

  

  The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced vG

• br Introduction The balance between hematopoietic stem

  2018-10-24

  

  Introduction The balance between hematopoietic stem cell (HSC) proliferation and quiescence is tightly regulated (He et al., 2009). Adult HSCs are usually quiescent, but their proliferation rates increase upon exposure to cytokines (Baldridge et al., 2010; Essers et al., 2009; Morrison et al., 19

• Among the epigenetic aberrations of iPSCs DNA methylation is

  2018-10-24

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• Traditionally testing of hPSC lines for gross chromosomal ch

  2018-10-24

  

  Traditionally, testing of hPSC lines for gross chromosomal changes employed karyology by chromosome banding of metaphase nuciferine (Amps et al., 2011; Baker et al., 2007). Although karyotyping allows examination of the entire cell genome in a single assay, an often overlooked issue in evaluating h

• SAG Overall our data support the view

  2018-10-24

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• A complementary study confirms our findings that GATA is nec

  2018-10-24

  

  A complementary study confirms our findings that GATA6 is necessary for 10058-F4 specification as well as the decreased efficiency of β-like cell generation from the GATA6 PSC line (Shi et al., 2017). This other report did have one major discrepancy with our results; they did not see a defect in gl

• br Methods br Results In there were

  2018-10-24

  

  Methods Results In 1860 there were 1100 counties within the boundaries of states legally permitting slavery (Upper South: 621; Deep South: 479), and in 2010 these same states consisted of 1,347 counties or county equivalents (716 and 624 for the Upper and Deep South, respectively). Spatial int

• However after several decades of

  2018-10-24

  

  However, after several decades of globalisation and neoliberal economic policies, long-term employment contracts and a high level of job security have become less GSK1120212 on the labour market. Instead, precarious work, i.e. short-term contracts, involuntary part time employment, employment throug

• HFI is operationally defined as the lack of access to

  2018-10-24

  

  HFI is operationally defined as the lack of access to food because of financial constraints (Tarasuk, Dachner & Loopstra, 2014) and in Canada is measured through national survey responses to the Household Food Security Survey Module (HFSSM) (Bickel, Nord, Price, Hamilton & Cook, 2000; Health Canada,

• We address this problem from

  2018-10-24

  

  We address this problem from a computational modeling point of view, and build an ABM that simulates the outcomes of different targeting methods including selected realistic factors that may interact. There exists a limited but rapidly developing literature for modeling social influence on obesity p

• A growing body of literature has developed to formally prese

  2018-10-24

  

  A growing body of literature has developed to formally present these assumptions and discuss their implications for policy makers (Harper et al., 2010). In that spirit, the present analysis seeks to show that efforts to improve overall population health may disadvantage some groups; whether equity o

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